4-hydroxymephobarbital

Base Information

• Chemical Name: 4-hydroxymephobarbital
• CAS No.: 790-25-0
• Molecular Formula: C₁₂H₇N₃O₄
• Molecular Weight: 0
• Mol file: 790-25-0.mol

Synonyms:4-hydroxymephobarbital

Chemical Property of 4-hydroxymephobarbital

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxymephobarbital

There total 5 articles about 4-hydroxymephobarbital which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5-Nitro-2-furancarboxamide oxime (772-43-0) + benzonitrile (100-47-0) → 5-Phenyl-3-(5-nitro-2-furyl)-1,2,4-oxadiazole (790-25-0)

Guidance literature:

With hydrogenchloride; zinc(II) chloride; at 110 - 120 ℃; for 1h;

DOI:10.1016/S0040-4020(01)90529-0

Reference yield: 46.0%

N-benzyl(5-nitrofur-2-yl)carboxamide oxime (18481-80-6) → 5-Phenyl-3-(5-nitro-2-furyl)-1,2,4-oxadiazole (790-25-0)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 40h; Ambient temperature;

Reference yield:

N-hydroxy-5-nitrofuran-2-carbimidoyl chloride (22296-92-0) → 5-Phenyl-3-(5-nitro-2-furyl)-1,2,4-oxadiazole (790-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / Et₃N / diethyl ether / 1 h / 20 - 25 °C

2: 46 percent / MnO₂ / CH₂Cl₂ / 40 h / Ambient temperature

With manganese(IV) oxide; triethylamine; In diethyl ether; dichloromethane;

upstream raw materials:

5-Nitro-2-furancarboxamide oxime

benzonitrile

N-benzyl(5-nitrofur-2-yl)carboxamide oxime

N-hydroxy-5-nitrofuran-2-carbimidoyl chloride

Refernces

• 1、 Yarovenko,Taralashvili,Zavarzin,Krayushkin. "New synthesis of 1,2,4-oxadiazoles". . p. 3941 - 3952. Retrieved 2007/10/02.