2-chlorooxazolo[5,4-b]pyridine

Base Information

• Chemical Name: 2-chlorooxazolo[5,4-b]pyridine
• CAS No.: 159870-95-8
• Molecular Formula: C6H3ClN2O
• Molecular Weight: 154.55382
• Hs Code.: 2934999090
• Mol file: 159870-95-8.mol

Synonyms:2-chlorooxazolo[5,4-b]pyridine

Chemical Property of 2-chlorooxazolo[5,4-b]pyridine

Chemical Property:

• Boiling Point: 215.9±13.0 °C(Predicted)
• PKA: -0.57±0.50(Predicted)
• PSA: 38.92000
• Density: 1.475±0.06 g/cm3(Predicted)
• LogP: 1.87620
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

2-Chlorooxazolo[5,4-b]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chlorooxazolo[5,4-b]pyridine

There total 3 articles about 2-chlorooxazolo[5,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Mercaptooxazolo<5,4-b>pyridine (169205-99-6) → 2-chloro-[1,3]oxazolo[5,4-b]pyridine (159870-95-8)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 110 ℃; for 2h;

Reference yield:

2-hydroxy-3-aminopyridine (33630-99-8) → 2-chloro-[1,3]oxazolo[5,4-b]pyridine (159870-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / 110 °C

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

2-hydroxy-3-nitropyridine (6332-56-5) → 2-chloro-[1,3]oxazolo[5,4-b]pyridine (159870-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol; ethanol / 16 h / 20 °C / 3102.97 Torr / Inert atmosphere

2: tetrahydrofuran / 16 h / 20 °C

3: thionyl chloride; N,N-dimethyl-formamide / 2 h / Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol;

upstream raw materials:

2-Mercaptooxazolo<5,4-b>pyridine

2-hydroxy-3-aminopyridine

2-hydroxy-3-nitropyridine

Refernces

• 1、 -. "SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 131; 132. . Retrieved 2019/03/17.