3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester
• CAS No.: 59288-40-3
• Molecular Formula: C₈H₈INO₃
• Molecular Weight: 293.061
• Hs Code.: 2933399090
• Mol file: 59288-40-3.mol

Synonyms:3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester;ethyl 5-hydroxy-6-iodonicotinate;5-hydroxy-6-iodo-3-Pyridinecarboxylic acid ethyl ester;5-Hydroxy-6-iodo-nicotinic acid ethyl ester

Chemical Property of 3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 388.923°C at 760 mmHg
• Flash Point: 189.014°C
• PSA: 59.42000
• Density: 1.86g/cm³
• LogP: 1.56850
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl5-hydroxy-6-iodonicotinate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester

There total 3 articles about 3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 5-hydroxy-3-pyridinecarboxylate (59288-38-9) → ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate (59288-40-3)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃;

DOI:10.1039/d0nj05600f

Reference yield:

5-hydroxynicotinic acid (27828-71-3) → ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate (59288-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Reflux

2: iodine; sodium carbonate / water / 2 h / 20 °C

With thionyl chloride; iodine; sodium carbonate; In water;

Reference yield:

→ ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate (59288-40-3)

Guidance literature:

Ester II, NH3, I2, KI;

DOI:10.1007/BF01106661

upstream raw materials:

5-hydroxynicotinic acid

ethyl 5-hydroxy-3-pyridinecarboxylate

Downstream raw materials:

ethyl furo[3,2-b]pyridine-6-carboxylate

Refernces

• 1、 -. "Synthesis method for 4-(tert-butoxycarbonyl) octahydrofuro[3,2-b] pyridine-6-carboxylic acid". . . Retrieved 2016/12/16.