2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione
• CAS No.: 329710-82-9
• Molecular Formula: C11H8F3NO3
• Molecular Weight: 259.1813296
• Hs Code.: 2933790090
• Mol file: 329710-82-9.mol

Synonyms:2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione;2-(2-Trifluoromethoxy-ethyl)-isoindole-1,3-dione

Chemical Property of 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione

Chemical Property:

• PSA: 46.61000
• LogP: 1.75690

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(2-(Trifluoromethoxy)ethyl)isoindoline-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione

There total 8 articles about 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] S-methyl dithiocarbonate → N-[2-(trifluoromethoxy)ethyl]phthalimide (329710-82-9)

Guidance literature:

With pyridine hydrofluoride; beta-hexachlorocyclohexane; In dichloromethane; at -78 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.3390/molecules22050804

Reference yield: 93.0%

2-[2-(trichloromethoxy)ethyl]-1H-isoindole-1,3(2H)-dione → N-[2-(trifluoromethoxy)ethyl]phthalimide (329710-82-9)

Guidance literature:

With hydrogen fluoride; antimonypentachloride; at -40 - 95 ℃; for 3h; Reagent/catalyst; Autoclave; Inert atmosphere;

DOI:10.3390/molecules22050804

Reference yield: 91.0%

2-(dimethylamino)-1,3-dimethylimidazolidin-2-ylium trifluoromethanolate (1006904-71-7) + 2-(1,3-dioxoisoindolin-2-yl)ethyl trifluoromethanesulfonate (127175-39-7) → N-[2-(trifluoromethoxy)ethyl]phthalimide (329710-82-9)

Guidance literature:

In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2007.11.105

upstream raw materials:

potassium phtalimide

2-(trifluoromethoxy)ethyl trifluoromethanesulphonate

2-(dimethylamino)-1,3-dimethylimidazolidin-2-ylium trifluoromethanolate

2-(1,3-dioxoisoindolin-2-yl)ethyl trifluoromethanesulfonate

Downstream raw materials:

2-(trifluoromethoxy)ethylamine hydrochloride