(S)-1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: (S)-1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID
• CAS No.: 210533-45-2
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Mol file: 210533-45-2.mol

Synonyms:(S)-1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID;(2S)-1-(PHENYLMETHYL)-2-PIPERIDINECARBOXYLIC ACID;(2S)-1-Benzyl-2-piperidinecarboxylic acid

Chemical Property of (S)-1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 358.6±35.0 °C(Predicted)
• PKA: 2.37±0.20(Predicted)
• PSA: 40.54000
• Density: 1.165
• LogP: 2.06360

Purity/Quality:

98%min ^*data from raw suppliers

(S)-1-Benzylpiperidine-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID

There total 7 articles about (S)-1-BENZYL-PIPERIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-5-bromo-1-cyanopentyl alcohol (164472-77-9) → (-)-(2S)-1-benzylpiperidine-2-carboxylic acid (210533-45-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 24 h / -65 °C

3: Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

4: HCl gas / 24 h / 0 °C

5: 0.5 N aq. HCl / ethanol / 48 h / 0 °C

6: 6 N aq. HCl / 10 h / Heating

With pyridine; hydrogenchloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0957-4166(98)00140-2

Reference yield:

benzylamine (100-46-9) → (-)-(2S)-1-benzylpiperidine-2-carboxylic acid (210533-45-2)

Guidance literature:

Multi-step reaction with 5 steps

1: CH₂Cl₂ / 24 h / -65 °C

2: Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

3: HCl gas / 24 h / 0 °C

4: 0.5 N aq. HCl / ethanol / 48 h / 0 °C

5: 6 N aq. HCl / 10 h / Heating

With hydrogenchloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/S0957-4166(98)00140-2

Reference yield:

(S)-1-benzyl-2-cyanopiperidine (210533-39-4) → (-)-(2S)-1-benzylpiperidine-2-carboxylic acid (210533-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl gas / 24 h / 0 °C

2: 0.5 N aq. HCl / ethanol / 48 h / 0 °C

3: 6 N aq. HCl / 10 h / Heating

With hydrogenchloride; In ethanol;

DOI:10.1016/S0957-4166(98)00140-2

upstream raw materials:

(S)-1-benzyl-2-piperidinecarboxylic acid ethyl ester

(R)-5-bromo-1-cyanopentyl alcohol

benzylamine

(S)-1-benzyl-2-cyanopiperidine

Downstream raw materials:

pipecolinic acid

(-)-[(2S)-1-benzylpiperidine-2-yl]methanol

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