(2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester

Base Information

Chemical Name:(2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester
CAS No.:210533-44-1
Molecular Formula:C₁₅H₂₁NO₂
Molecular Weight:247.337
Hs Code.:
DSSTox Substance ID:DTXSID801222388
Nikkaji Number:J887.427A

Synonyms:DTXSID801222388;(2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester;Ethyl (2S)-1-(phenylmethyl)-2-piperidinecarboxylate;210533-44-1

Suppliers and Price of (2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:247.157228913
Heavy Atom Count:18
Complexity:261

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1CCCCN1CC2=CC=CC=C2
Isomeric SMILES:CCOC(=O)[C@@H]1CCCCN1CC2=CC=CC=C2

Technology Process of (2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester

There total 7 articles about (2S)-1-Benzyl-2-piperidinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-1-Benzyl-piperidine-2-carboximidic acid ethyl ester

: 210533-44-1
(S)-1-benzyl-2-piperidinecarboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; In ethanol; at 0 ℃; for 48h; Yield given;
DOI:10.1016/S0957-4166(98)00140-2

Reference yield:

: 100-39-0
benzyl bromide

: 22328-78-5
(S)-piperidine-2-carboxylic acid ethyl ester

: 210533-44-1
(S)-1-benzyl-2-piperidinecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1002/chem.201900635

Reference yield:

: 164472-77-9
(R)-5-bromo-1-cyanopentyl alcohol

: 210533-44-1
(S)-1-benzyl-2-piperidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

2: CH₂Cl₂ / 24 h / -65 °C

3: Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

4: HCl gas / 24 h / 0 °C

5: 0.5 N aq. HCl / ethanol / 48 h / 0 °C

With pyridine; hydrogenchloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/S0957-4166(98)00140-2