Technology Process of 2-bromo-5-methoxy-3-methylbenzaldehyde
There total 1 articles about 2-bromo-5-methoxy-3-methylbenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo202448e
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
Inert atmosphere;
2-bromo-5-methoxy-3-methylbenzaldehyde;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo202448e
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: triacetoxyborane; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 72 h / 20 °C / Inert atmosphere
3.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: bis-triphenylphosphine-palladium(II) chloride; formic acid; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / 3 h / -78 °C / Inert atmosphere
5.2: Inert atmosphere
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; formic acid; triacetoxyborane; potassium tert-butylate; boron tribromide; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
1.2: Wittig reaction / 2.1: Diels-Alder reaction;
DOI:10.1021/jo202448e
