Coronardine

Base Information

• Chemical Name: Coronardine
• CAS No.: 467-77-6
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.45
• European Community (EC) Number: 207-398-7
• NSC Number: 127490
• Nikkaji Number: J3.333.760D
• Wikipedia: Coronaridine
• Wikidata: Q104180067
• Mol file: 467-77-6.mol

Synonyms:coronardine;coronardine monohydrochloride;coronardine monohydrochloride, (+-)-isomer;coronaridine

Chemical Property of Coronardine

Chemical Property:

• Vapor Pressure: 1.12E-09mmHg at 25°C
• Boiling Point: 488.1°Cat760mmHg
• Flash Point: 249°C
• PSA: 45.33000
• Density: 1.24g/cm³
• LogP: 3.19310
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 338.199428076
• Heavy Atom Count: 25
• Complexity: 552

Purity/Quality:

99%, ^*data from raw suppliers

Coronaridine ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC
• Use Description: Methyl ibogamine-18-carboxylate, a specific chemical compound, serves distinct roles across various fields. In medicinal research, it plays a significant role as a potential precursor or intermediate in the synthesis of novel compounds for drug development, contributing to the exploration of new therapeutic agents. In organic chemistry, the compound functions as a building block, enabling the creation of complex molecular structures and supporting advancements in chemical research. Moreover, in ethnobotanical and pharmacological studies, it may contribute to understanding the properties and effects of related natural compounds. The compound's multifaceted applications in medicine, chemistry, and ethnobotany underscore its importance in driving innovation, scientific exploration, and potential medical breakthroughs across these different fields.

Technology Process of Coronardine

There total 32 articles about Coronardine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

16-(methoxycarbonyl)-Δ20-cleavamine (139133-16-7) → Dihydrocatharanthin (467-77-6,14241-45-3,14853-22-6,38542-83-5)

Guidance literature:

for 120h; under 0.005 Torr;

DOI:10.1021/jo00032a029

Reference yield: 80.0%

C21H24N2O2 → Coronaridin (467-77-6,14241-45-3,14853-22-6,38542-83-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 23 ℃;

DOI:10.1021/jacs.1c10205

Reference yield:

Δ5-catharanthine (77794-83-3) → dihydro-15,20 S-catharanthine (467-77-6,14241-45-3,14853-22-6,38542-83-5) + catharanthine (2468-21-5,20395-98-6,67110-66-1,113158-99-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 48h; Product distribution; Ambient temperature;

DOI:10.1016/0040-4020(80)88032-X

upstream raw materials:

16-(methoxycarbonyl)-Δ²⁰-cleavamine

methyl 4-formylhexanoate

4-(1,3-dioxolan-2-yl)-1-hexanol

4-(1,3-dioxolan-2-yl)hexanal

Downstream raw materials:

4-Epiibogamin

3-oxocoronaridine

19-hydroxycoronaridine

Refernces

• 1、 -. "Synthetic noribogaine". . . Retrieved 2017/05/02.
• 2、 Achenbach, Hans,Raffelsberger, Bernd. "19-ETHOXYCORONARIDINE, A NOVEL ALKALOID FROM TABERNAEMONTANA GLANDULOSA". . p. 716 - 717. Retrieved 2007/10/02.