4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Base Information

• Chemical Name: 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
• CAS No.: 779331-49-6
• Molecular Formula: C12H16BFO3
• Molecular Weight: 238.067
• Hs Code.: 2934999090
• Mol file: 779331-49-6.mol

Synonyms:4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol;5-Fluoro-2-hydroxyphenylboronic acid, pinacol ester

Chemical Property of 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Chemical Property:

• Boiling Point: 333.3±32.0 °C(Predicted)
• PKA: 10.10±0.48(Predicted)
• PSA: 38.69000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 1.83050
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-hydroxyphenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

There total 8 articles about 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-fluoro-2-methoxyphenyl)boronic acid (179897-94-0) → 4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (779331-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2: diethyl ether / 20 °C / Inert atmosphere

With boron tribromide; In diethyl ether; dichloromethane;

DOI:10.1002/anie.201303659

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + 5-fluoro-2-hydroxyphenyl-boronic acid (259209-20-6) → 4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (779331-49-6)

Guidance literature:

In diethyl ether; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201303659

Reference yield:

C24H25BFO3P → 4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (779331-49-6)

Guidance literature:

With hydrogenchloride; In octane; water; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d0cc02889d

upstream raw materials:

2,3-dimethyl-2,3-butane diol

5-fluoro-2-hydroxyphenyl-boronic acid

(5-fluoro-2-methoxyphenyl)boronic acid

4-Fluorophenol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 779331-49-6 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Send

Send

Metric Ton KG G Pound L ML

Send

Send