Butanediamide,2-[[(6-bromo-2-quinolinyl)- carbonyl]amino]-N1-[(1S,2R)-3-[(3S,4aS,- 8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]- octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1- (phenylmethyl)propyl]-,(2S)-

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Chemical Name:Butanediamide,2-[[(6-bromo-2-quinolinyl)- carbonyl]amino]-N1-[(1S,2R)-3-[(3S,4aS,- 8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]- octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1- (phenylmethyl)propyl]-,(2S)-
CAS No.:219959-35-0
Molecular Formula:C₃₈H₄₉BrN₆O₅
Molecular Weight:749.748
Hs Code.:
Mol file:219959-35-0.mol

Butanediamide,2-[[(6-bromo-2-quinolinyl)- carbonyl]amino]-N1-[(1S,2R)-3-[(3S,4aS,- 8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]- octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1- (phenylmethyl)propyl]-,(2S)-

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Chemical Property of Butanediamide,2-[[(6-bromo-2-quinolinyl)- carbonyl]amino]-N1-[(1S,2R)-3-[(3S,4aS,- 8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]- octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1- (phenylmethyl)propyl]-,(2S)-

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Technology Process of Butanediamide,2-[[(6-bromo-2-quinolinyl)- carbonyl]amino]-N1-[(1S,2R)-3-[(3S,4aS,- 8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]- octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1- (phenylmethyl)propyl]-,(2S)-

There total 6 articles about Butanediamide,2-[[(6-bromo-2-quinolinyl)- carbonyl]amino]-N1-[(1S,2R)-3-[(3S,4aS,- 8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]- octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1- (phenylmethyl)propyl]-,(2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 137431-06-2
2-[3(S)-[(L-asparaginyl)-amino]-2(R)-hydroxy-4-phenylbutyl]-N-tert-butyl-decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide

: 6-bromoquinaldic acid-hydroxysuccinimide ester

: 219959-35-0
N-tert.butyl-decahydro-2-[2-(R)-hydroxy-4-phenyl-3(S)-[{N-(2-[6-bromo]-quinolylcarbonyl)-L-asparaginyl}amino]butyl]-(4aS,8aS)-isoquinoline-3-carboxamide

Guidance literature:: In tetrahydrofuran; at 25 ℃;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1103::AID-JLCR157>3.0.CO;2-M

Reference yield:

: 877-42-9
6-Bromo-2-methyl-quinoline

: 219959-35-0
N-tert.butyl-decahydro-2-[2-(R)-hydroxy-4-phenyl-3(S)-[{N-(2-[6-bromo]-quinolylcarbonyl)-L-asparaginyl}amino]butyl]-(4aS,8aS)-isoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / Br₂; NaOAc / acetic acid / 2 h / 120 °C

2: 51 percent / aq. H₂SO₄ / tetrahydrofuran / Heating

3: 48 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 25 °C

4: 39 percent / tetrahydrofuran / 25 °C

With sulfuric acid; bromine; sodium acetate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetic acid; 1: Bromination / 2: Hydrolysis / 3: Esterification / 4: Substitution;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1103::AID-JLCR157>3.0.CO;2-M

Reference yield:

: 136522-18-4
2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

: 219959-35-0
N-tert.butyl-decahydro-2-[2-(R)-hydroxy-4-phenyl-3(S)-[{N-(2-[6-bromo]-quinolylcarbonyl)-L-asparaginyl}amino]butyl]-(4aS,8aS)-isoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / ethanol / 3.5 h

2: 39 percent / tetrahydrofuran / 25 °C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Hydrogenation / 2: Substitution;
DOI:10.1002/(SICI)1099-1344(199812)41:12<1103::AID-JLCR157>3.0.CO;2-M