137431-06-2Relevant articles and documents
Synthesis and biological evaluation of novel substitutedy-[1-benzyl-3-(3- tert-butylcarbamoyl-octahydroisoquinolin-2yl)-2-hydroxy-propyl] -2-[(2-oxo-2h-chromene-3-carbonyl) amino] succinamide analogs as anti-viral and anti-HIV agents
Reddy, Y. Thirupathi,Reddy, P. Narsimha,Crooks, Peter A.,Clercq, Erik De,Rao, G. V. Panakala,Rajitha
scheme or table, p. 419 - 426 (2010/03/24)
A series of novel substituted N1 [1-benzy1-3-(3-tert- butylcarbamoyloctahydroisoquinolin-2y1)-2-hydroxypropyl]-2-[(2-oxo-2H-chromene- 3-carbonyl) amino] succinamide analogs has been synthesized and evaluated for their anti-viral activity agains
Synthesis of the HIV-proteinase inhibitor Saquinavir: A challenge for process research
Goehring, Wolfgang,Gokhale, Surendra,Hilpert, Hans,Roessler, Felix,Schlageter, Markus,Vogt, Peter
, p. 532 - 537 (2007/10/03)
The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir (1), a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.