Ethyl 1-Boc-3-fluoropiperidine-3-carboxylate

Base Information

• Chemical Name: Ethyl 1-Boc-3-fluoropiperidine-3-carboxylate
• CAS No.: 1228631-45-5
• Molecular Formula: C₁₃H₂₂FNO₄
• Molecular Weight: 275.32
• Hs Code.: 2933399090
• Mol file: 1228631-45-5.mol

Synonyms:Ethyl 1-Boc-3-fluoropiperidine-3-carboxylate;Ethyl 1-Boc-3-fluoropiper...;1-tert-butyl 3-ethyl 3-fluoropiperidine-1,3-dicarboxylate;1-O-tert-butyl 3-O-ethyl 3-fluoropiperidine-1,3-dicarboxylate

Chemical Property of Ethyl 1-Boc-3-fluoropiperidine-3-carboxylate

Chemical Property:

• PSA: 55.84000
• LogP: 2.22660

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl1-Boc-3-fluoropiperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 1-Boc-3-fluoropiperidine-3-carboxylate

There total 3 articles about Ethyl 1-Boc-3-fluoropiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) → (±)-1-tert-butyl 3-ethyl 3-fluoropiperidine-1,3-dicarboxylate (1228631-45-5)

Guidance literature:

ethyl N-(t-butyloxycarbonyl)nipecotate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -20 ℃; for 1h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (±)-1-tert-butyl 3-ethyl 3-fluoropiperidine-1,3-dicarboxylate (1228631-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 2.25 h / -78 - 20 °C

With triethylamine; lithium diisopropyl amide; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

Ethyl nipecotate (71962-74-8) → (±)-1-tert-butyl 3-ethyl 3-fluoropiperidine-1,3-dicarboxylate (1228631-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -78 °C

2.2: 2.25 h / -78 - 20 °C

With triethylamine; lithium diisopropyl amide; dmap; In tetrahydrofuran; dichloromethane;

upstream raw materials:

ethyl N-(t-butyloxycarbonyl)nipecotate

di-tert-butyl dicarbonate

Ethyl nipecotate

Downstream raw materials:

tert-butyl 3-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate

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