tert-butyl 3-(aMinoMethyl)-3-fluoropiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(aMinoMethyl)-3-fluoropiperidine-1-carboxylate
• CAS No.: 1209781-11-2
• Molecular Formula: C11H21FN2O2
• Molecular Weight: 232.2950432
• Hs Code.: 2933399090
• Mol file: 1209781-11-2.mol

Synonyms:tert-butyl 3-(aMinoMethyl)-3-fluoropiperidine-1-carboxylate;3-FLUORO-3-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-3-fluoropiperidine-3-Methanol;tert-Butyl 3-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 3-(aMinoMethyl)-3-fluoropiperidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 1.65580

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl3-Fluoro-3-(hydroxymethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-(aMinoMethyl)-3-fluoropiperidine-1-carboxylate

There total 11 articles about tert-butyl 3-(aMinoMethyl)-3-fluoropiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(tert-butoxycarbonyl)-3-fluoropiperidine-3-carboxylic acid (934342-39-9) → tert-butyl 3-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate (1209781-11-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield: 74.2%

(±)-1-tert-butyl 3-ethyl 3-fluoropiperidine-1,3-dicarboxylate (1228631-45-5) → tert-butyl 3-fluoro-3-(hydroxymethyl)piperidine-1-carboxylate (1209781-11-2)

Guidance literature:

(±)-1-tert-butyl 3-ethyl 3-fluoropiperidine-1,3-dicarboxylate; With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 4h;

With ammonium chloride; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

Reference yield: 72.0%

di-tert-butyl dicarbonate (24424-99-5) + (1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl(3S)-3-fluoro-2-oxo-3-piperidinecarboxylate (1345459-64-4) → 1,1-dimethylethyl (3S)-3-fluoro-3-(hydroxymethyl)-1-piperidinecarboxylate (1345697-13-3,1209781-11-2)

Guidance literature:

(1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl(3S)-3-fluoro-2-oxo-3-piperidinecarboxylate; With dimethylsulfide borane complex; In tetrahydrofuran; at 67 ℃; for 43h; Large scale;

di-tert-butyl dicarbonate; In tert-butyl methyl ether; at 20 ℃; for 2h; Large scale;

DOI:10.1021/acs.oprd.5b00131

upstream raw materials:

di-tert-butyl dicarbonate

ethyl (3S)-3-fluoro-2-oxo-3-piperidinecarboxylate

(1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexyl(3S)-3-fluoro-2-oxo-3-piperidinecarboxylate

3-carboethoxy-2-pyridone

Downstream raw materials:

7-[3,4-bis(methyloxy)phenyl]-N-{[(3S)-3-fluoro-3-piperidinyl]methyl}pyrido[3,4-b]pyrazin-5-amine hydrochloride

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