2-AMino-3-fluoro-5-iodopyridine

Base Information

• Chemical Name: 2-AMino-3-fluoro-5-iodopyridine
• CAS No.: 1321612-85-4
• Molecular Formula: C5H4FIN2
• Molecular Weight: 238.0015332
• Hs Code.: 2933399990
• Mol file: 1321612-85-4.mol

Synonyms:2-AMino-3-fluoro-5-iodopyridine;3-Fluoro-5-iodo-pyridin-2-ylaMine;2-Pyridinamine, 3-fluoro-5-iodo-

Chemical Property of 2-AMino-3-fluoro-5-iodopyridine

Chemical Property:

• Boiling Point: 254.7±40.0 °C(Predicted)
• PKA: 1.96±0.49(Predicted)
• PSA: 38.91000
• Density: 2.139±0.06 g/cm3(Predicted)
• LogP: 1.98870
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-5-iodopyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-3-fluoro-5-iodopyridine

There total 2 articles about 2-AMino-3-fluoro-5-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 3-fluoro-5-iodo-2-pyridinamine (1321612-85-4)

Guidance literature:

Reference yield:

3-fluoropyridin-2-amine (21717-95-3) → 3-fluoro-5-iodo-2-pyridinamine (1321612-85-4)

Guidance literature:

With N-iodo-succinimide; acetic acid; at 0 - 20 ℃; for 5h; Inert atmosphere;

Reference yield: 76.0%

5-(tert-butoxycarbonylamino)-2-chlorobenzoic acid (503555-96-2) + 3-fluoro-5-iodo-2-pyridinamine (1321612-85-4) → tert-butyl (4-chloro-3-((3-fluoro-5-iodopyridin-2-yl)carbamoyl)phenyl)carbamate

Guidance literature:

With pyridine; 1-propanephosphonic anhydride; In dichloromethane; ethyl acetate; at 20 ℃; for 19h;

upstream raw materials:

3-fluoropyridin-2-amine

Downstream raw materials:

5-((4-bromophenyl)sulfanyl)-3-fuoro-2-pyridinamine

5-((4-bromophenyl)sulfonyl)-3-fluoro-2-pyridinamine

3-fluoro-5-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)-2-pyridinamine