Technology Process of 3-fluoro-5-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)-2-pyridinamine
There total 4 articles about 3-fluoro-5-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)-2-pyridinamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-((4-bromophenyl)sulfonyl)-3-fluoro-2-pyridinamine; bis(pinacol)diborane;
With
potassium acetate;
In
toluene;
at 20 ℃;
for 0.25h;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
toluene;
at 80 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; N-iodo-succinimide / 5 h / 0 - 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide / 0.17 h / 20 °C
3.1: acetic acid; dihydrogen peroxide; sodium tungstate / water / 0.5 h / 0 - 20 °C
4.1: potassium acetate / toluene / 0.25 h / 20 °C
4.2: 2 h / 80 °C / Inert atmosphere
With
sodium tungstate; N-iodo-succinimide; dihydrogen peroxide; potassium acetate; acetic acid;
In
water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid; dihydrogen peroxide; sodium tungstate / water / 0.5 h / 0 - 20 °C
2.1: potassium acetate / toluene / 0.25 h / 20 °C
2.2: 2 h / 80 °C / Inert atmosphere
With
sodium tungstate; dihydrogen peroxide; potassium acetate; acetic acid;
In
water; toluene;
