4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-

Base Information

Chemical Name:4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-
CAS No.:681854-00-2
Molecular Formula:C28H28O4
Molecular Weight:428.51952
Hs Code.:
Mol file:681854-00-2.mol

Synonyms:4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-;4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-6

Suppliers and Price of 4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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ChemScene
4H-Cyclopenta-1,3-dioxol-4-ol,3a,6a-dihydro-2,2-dimethyl-4-[(triphenylmethoxy)methyl]-,(3aS,4S,6aS)-
100mg
$ 2750.00

Total 6 raw suppliers

Chemical Property of 4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-

Chemical Property:

PSA：47.92000
LogP:4.81610

Purity/Quality:

NLT 98% ^*data from raw suppliers

4H-Cyclopenta-1,3-dioxol-4-ol,3a,6a-dihydro-2,2-dimethyl-4-[(triphenylmethoxy)methyl]-,(3aS,4S,6aS)- ^*data from reagent suppliers

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Technology Process of 4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)-

There total 14 articles about 4H-Cyclopenta-1,3-dioxol-4-ol, 3a,6a-dihydro-2,2-diMethyl-4-[(triphenylMethoxy)Methyl]-, (3aS,4S,6aS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 865838-12-6
(1R)-(-)-1-[(4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-1-(triphenylmethyloxymethyl)-2-propen-1-ol

: 865838-13-7,681854-00-2
(3aS,4R,6aS)-2,2-dimethyl-4-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jo0356762

Reference yield: 94.0%

: 902799-71-7
C₃₀H₃₂O₄

: 865838-13-7,681854-00-2
(3aS,4R,6aS)-2,2-dimethyl-4-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; at 20 ℃;
DOI:10.1081/NCN-200061832

Reference yield:

: 54503-64-9,54503-65-0
2,3-O-isopropylidene-5-O-trityl-D-ribofuranose

: 865838-13-7,681854-00-2
(3aS,4R,6aS)-2,2-dimethyl-4-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / potassium t-butoxide / tetrahydrofuran / 20 °C

2: 90 percent / oxalyl chloride; triethylamine; DMSO / CH₂Cl₂ / -78 - 20 °C

3: 100 percent / tetrahydrofuran / -78 °C

4: 94 percent / Grubbs catalyst / CH₂Cl₂ / 20 °C

With oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; triethylamine; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; 1: Wittig reaction / 3: Grignard reaction;
DOI:10.1081/NCN-200061832