Methyl 5,6-diMethylnicotinate

Base Information

• Chemical Name: Methyl 5,6-diMethylnicotinate
• CAS No.: 1174028-18-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Hs Code.: 2933399090
• Mol file: 1174028-18-2.mol

Synonyms:Methyl 5,6-diMethylnicotinate;5,6-Dimethyl-nicotinic acid methyl ester

Chemical Property of Methyl 5,6-diMethylnicotinate

Chemical Property:

• Boiling Point: 245.5±35.0 °C(Predicted)
• PKA: 4.21±0.20(Predicted)
• PSA: 39.19000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 1.48500
• Storage Temp.: 2-8°C

Purity/Quality:

≥99.0% ^*data from raw suppliers

5,6-Dimethyl-nicotinicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5,6-diMethylnicotinate

There total 3 articles about Methyl 5,6-diMethylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethylboroxine (823-96-1) + 5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester (78686-77-8) → 5,6-dimethylnicotinic acid methyl ester (1174028-18-2)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

methyl 2,3-dichloro-pyridine-5-carboxylate (56055-54-0) + dihydroxy-methyl-borane (13061-96-6) → 5,6-dimethylnicotinic acid methyl ester (1174028-18-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 110 ℃;

Reference yield:

5,6-dichloronicotinic acid (41667-95-2) → 5,6-dimethylnicotinic acid methyl ester (1174028-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 25 °C

2: potassium carbonate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 110 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane;

upstream raw materials:

Trimethylboroxine

5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester

methyl 2,3-dichloro-pyridine-5-carboxylate

dihydroxy-methyl-borane

Downstream raw materials:

5,6-dimethylpyridine-3-carboxylic acid

C₁₀H₁₃NO₄

C₁₀H₁₂ClNO₃

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 22. . Retrieved 2015/12/17.
• 2、 -. "COMPOUNDS". Page/Page column 30. . Retrieved 2009/12/24.