(R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide

Base Information

Chemical Name:(R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide
CAS No.:27262-43-7
Molecular Formula:C₁₄H₂₀N₂O
Molecular Weight:232.326
Hs Code.:
UNII:I4587B32M8
DSSTox Substance ID:DTXSID70181714
Nikkaji Number:J958.389K
Wikidata:Q27280399
Mol file:27262-43-7.mol

Synonyms:27262-43-7;N-Despropyl (R)-Ropivacaine;(-)-2',6'-Pipecoloxylidide;(R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide;2',6'-Pipecoloxylidide, (-)-;Demethylmepivacaine, (-)-;Desbutylbupivacaine, (-)-;2-PIPERIDINECARBOXAMIDE, N-(2,6-DIMETHYLPHENYL)-, (2R)-;(-)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide;UNII-I4587B32M8;(2R)-N-(2,6-DIMETHYLPHENYL)PIPERIDINE-2-CARBOXAMIDE;I4587B32M8;(2R)-Pipecoloxylidide;SCHEMBL15428917;DTXSID70181714;2/',6/'-Pipecoloxylidide, (-)-;Q27280399

Suppliers and Price of (R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Despropyl(R)-Ropivacaine
25mg
$ 130.00

Biosynth Carbosynth
N-Despropyl (R)-ropivacaine
250 mg
$ 1640.00

Biosynth Carbosynth
N-Despropyl (R)-ropivacaine
100 mg
$ 901.00

Biosynth Carbosynth
N-Despropyl (R)-ropivacaine
50 mg
$ 496.00

Biosynth Carbosynth
N-Despropyl (R)-ropivacaine
25 mg
$ 272.50

Biosynth Carbosynth
N-Despropyl (R)-ropivacaine
10 mg
$ 149.90

Total 9 raw suppliers

Chemical Property of (R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide

Chemical Property:

Boiling Point:392.3±42.0 °C(Predicted)
PKA:14.85±0.70(Predicted)
PSA：44.62000
Density:1.087±0.06 g/cm3(Predicted)
LogP:3.36230
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:232.157563266
Heavy Atom Count:17
Complexity:257

Purity/Quality:

99% ^*data from raw suppliers

N-Despropyl(R)-Ropivacaine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2
Isomeric SMILES:CC1=C(C(=CC=C1)C)NC(=O)[C@H]2CCCCN2
Uses A major metabolite of (R)-enantiomers of Bupivacaine (B689545) and the anesthetic Ropivacaine (R675005). N-Despropyl (R)-Ropivacaine is a major metabolite of (R)-enantiomers of Bupivacaine (B689545) and the anesthetic Ropivacaine (R675005).

Technology Process of (R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide

There total 24 articles about (R)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

: [Cbz-piperidine-2-carboxylic acid (2,6-dimethyl-phenyl)-amide]

: 15883-20-2,27262-40-4,27262-43-7,78341-12-5
2',6'-pipecoloxylidide

Guidance literature:: With hydrogen; palladium on activated carbon; In methanol; for 0.5h;

Reference yield: 90.0%

: (R)-2',6'-pipecoloxylidide

: 15883-20-2,27262-40-4,27262-43-7,78341-12-5
2',6'-pipecoloxylidide

Guidance literature:: With sodium hydroxide; In water; for 36h; Reflux;

Reference yield: 84.5%

: 87-62-7
2,6-dimethylaniline

: 4043-87-2,83680-83-5
pipecolic Acid

: 15883-20-2,27262-40-4,27262-43-7,78341-12-5
2',6'-pipecoloxylidide

Guidance literature:: pipecolic Acid; With hydrogenchloride; thionyl chloride; In N,N-dimethyl-formamide; toluene; at 45 - 55 ℃; for 3h; pH=2;

2,6-dimethylaniline; In N,N-dimethyl-formamide; toluene; for 2h; Solvent; Temperature; pH-value;