CYCLIC-PIFITHRIN-ALPHA

Base Information

• Chemical Name: CYCLIC-PIFITHRIN-ALPHA
• CAS No.: 60477-34-1
• Molecular Formula: C16H16N2S.BrH
• Molecular Weight: 268.382
• Mol file: 60477-34-1.mol

Synonyms:Pifithrin-alpha (cyclic) . HBr;5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole

Chemical Property of CYCLIC-PIFITHRIN-ALPHA

Chemical Property:

• Melting Point: 266.4-267.3 °C(lit.)
• PKA: 6.75±0.20(Predicted)
• PSA: 45.54000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 4.25000
• Storage Temp.: −20°C
• Solubility.: DMSO: 20 mg/mL

Purity/Quality:

97% ^*data from raw suppliers

Pifithrin-α, Cyclic- - CAS 60477-34-1 - CalbiochemA cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity. ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLIC-PIFITHRIN-ALPHA

There total 6 articles about CYCLIC-PIFITHRIN-ALPHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pifithrin-α (63208-82-2) → 2-(4-methylphenyl)-5,6,7,8-tetrahydrobenzo[d]-imidazo[2,1-b]thiazole (60477-34-1)

Guidance literature:

With biological medium; at 37 ℃; for 6h;

DOI:10.1021/jm060318n

Reference yield: 78.0%

2-Amino-4,5,6,7-tetrahydrobenzothiazole (2933-29-1) + 4-(bromoacetyl)toluene (619-41-0) → 2-(4-methylphenyl)-5,6,7,8-tetrahydrobenzo[d]-imidazo[2,1-b]thiazole (60477-34-1)

Guidance literature:

In ethanol; for 1.5h; Reflux;

Reference yield:

2-Amino-4,5,6,7-tetrahydrobenzothiazole (2933-29-1) → 2-(4-methylphenyl)-5,6,7,8-tetrahydrobenzo[d]-imidazo[2,1-b]thiazole (60477-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / toluene / 48 h / 20 °C

2: 100 percent / biological medium / 6 h / 37 °C

With biological medium; In toluene;

DOI:10.1021/jm060318n

upstream raw materials:

2-Amino-4,5,6,7-tetrahydrobenzothiazole

4-(bromoacetyl)toluene

pifithrin‐α

pifithrin-α

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