1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

Base Information

• Chemical Name: 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone
• CAS No.: 1352306-11-6
• Molecular Formula: C24H28O6
• Molecular Weight: 412.483
• Mol file: 1352306-11-6.mol

Synonyms:1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone;1-(2-Hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phen

Chemical Property of 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

Chemical Property:

• PSA: 74.22000
• LogP: 4.62840

Purity/Quality:

1-(2-Hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

There total 7 articles about 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dihydro-2H-pyran (110-87-2) + 1-(2,5-dihydroxyphenyl)-2-(3-hydroxyphenyl)ethanone (1352306-12-7) → 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone (1352306-11-6)

Guidance literature:

pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

1-(2,5-dimethoxyphenyl)-2-(3-methoxyphenyl)ethanone (1097016-89-1) → 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone (1352306-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 0.5 h / -78 - 0 °C

1.2: -78 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C

With boron tribromide; pyridinium p-toluenesulfonate; In dichloromethane;

Reference yield:

2,5-dimethoxybenzoic acid (2785-98-0) → 1-(2-hydroxy-5-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone (1352306-11-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: magnesium / iodine / tetrahydrofuran / 1.75 h / 60 °C

3.2: 1 h / 0 °C

4.1: boron tribromide / dichloromethane / 0.5 h / -78 - 0 °C

4.2: -78 °C

5.1: pyridinium p-toluenesulfonate / dichloromethane / 1 h / 20 °C

With oxalyl dichloride; boron tribromide; magnesium; triethylamine; iodine; pyridinium p-toluenesulfonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2,5-dimethoxybenzoic acid

3,4-dihydro-2H-pyran

1-(2,5-dihydroxyphenyl)-2-(3-hydroxyphenyl)ethanone

2,5-dimethoxybenzoyl chloride

Downstream raw materials:

2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)chroman-4-one

(R)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol

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