ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate

Base Information

• Chemical Name: ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate
• CAS No.: 1333340-14-9
• Molecular Formula: C₁₇H₁₁BrFNO₅
• Molecular Weight: 408.18
• Mol file: 1333340-14-9.mol

Synonyms:ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate

Chemical Property of ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate

There total 5 articles about ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate (1333340-13-8) → ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate (1333340-14-9)

Guidance literature:

With nitric acid; In chloroform; at -15 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2014.02.051

Reference yield:

C17H12Br2FNO5 → ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate (1333340-14-9)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 60 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01598

Reference yield:

ethyl 3-(4'-fluorophenyl)-3-oxopropionate (1999-00-4) → ethyl 5-bromo-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate (1333340-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: di-tert-butyl peroxide; iron(III) chloride hexahydrate / 1,2-dichloro-ethane / 6 h / Inert atmosphere; Reflux

2: nitric acid / chloroform / 0.5 h / -15 °C

With di-tert-butyl peroxide; iron(III) chloride hexahydrate; nitric acid; In chloroform; 1,2-dichloro-ethane;

DOI:10.1016/j.tetlet.2014.02.051

upstream raw materials:

1-(4-fluorophenyl)ethanone

ethyl 3-(4'-fluorophenyl)-3-oxopropionate

ethyl 5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

1,4-dibromo-2-fluoro-5-nitrobenzene

Downstream raw materials:

5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide

5-bromo-2-(4-fluoro-phenyl)-6-methanesulfonylamino-benzofuran-3-carboxylic acid ethyl ester

5-bromo-2-(4-fluoro-phenyl)-6-methanesulfonylamino-benzofuran-3-carboxylic acid

5-bromo-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide