Technology Process of 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide
There total 23 articles about 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)-1-benzofuran-3-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
methylamine hydrochloride;
With
triethylamine;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
2.1: hydrogenchloride / water; acetone / 1 h / Reflux
3.1: nitric acid / chloroform / 4 h / 20 °C
4.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux
5.1: pyridine / dichloromethane / 15 h / 0 - 20 °C
6.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 15 h / Inert atmosphere; Reflux
7.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / Reflux
7.2: pH 3
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
8.2: 15 h
With
pyridine; hydrogenchloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; nitric acid; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux
2.1: pyridine / dichloromethane / 15 h / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 15 h / Inert atmosphere; Reflux
4.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / Reflux
4.2: pH 3
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 15 h
With
pyridine; lithium hydroxide monohydrate; water; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
