Technology Process of 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide
There total 23 articles about 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-bromo-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)-1-benzofuran-3-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
methylamine hydrochloride;
With
triethylamine;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
2.1: hydrogenchloride / water; acetone / 1 h / Reflux
3.1: nitric acid / chloroform / 4 h / 20 °C
4.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux
5.1: pyridine / dichloromethane / 15 h / 0 - 20 °C
6.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 15 h / Inert atmosphere; Reflux
7.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / Reflux
7.2: pH 3
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
8.2: 15 h
With
pyridine; hydrogenchloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; nitric acid; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux
2.1: pyridine / dichloromethane / 15 h / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 15 h / Inert atmosphere; Reflux
4.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / Reflux
4.2: pH 3
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 15 h
With
pyridine; lithium hydroxide monohydrate; water; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;