4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride

Base Information

• Chemical Name: 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride
• CAS No.: 1199782-88-1
• Molecular Formula: C9H10ClF2N
• Molecular Weight: 205.6322064
• Hs Code.: 2921309990
• Mol file: 1199782-88-1.mol

Synonyms:4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride

Chemical Property of 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride

Chemical Property:

• PSA: 26.02000
• LogP: 3.41310
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4,6-Difluoro-2,3-dihydro-1H-inden-1-aminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride

There total 4 articles about 4,6-Difluoro-2,3-dihydro-1H-inden-1-aMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(R)-N-((R)-4,6-difluoroindan-1-yl)-2-methylpropane-2-sulfinamide → (R)-4,6-difluoroindan-1-ylamine hydrochloride (1199782-88-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2020.115903

Reference yield:

C13H15F2NOS → (R)-4,6-difluoroindan-1-ylamine hydrochloride (1199782-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 12.17 h / 0 - 20 °C

2: hydrogenchloride / methanol; water; 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1016/j.bmc.2020.115903

Reference yield:

4,6-difluoroindan-1-one (162548-73-4) → (R)-4,6-difluoroindan-1-ylamine hydrochloride (1199782-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2: sodium tetrahydroborate / tetrahydrofuran / 12.17 h / 0 - 20 °C

3: hydrogenchloride / methanol; water; 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; In tetrahydrofuran; 1,4-dioxane; methanol; water;

DOI:10.1016/j.bmc.2020.115903

upstream raw materials:

4,6-difluoroindan-1-one

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