4,6-Difluoro-1-indanone

Base Information

Chemical Name:4,6-Difluoro-1-indanone
CAS No.:162548-73-4
Molecular Formula:C9H6F2O
Molecular Weight:168.14
Hs Code.:2914790090
European Community (EC) Number:622-366-6
DSSTox Substance ID:DTXSID60449557
Wikidata:Q72462997
Mol file:162548-73-4.mol

Synonyms:4,6-Difluoro-1-indanone;162548-73-4;4,6-difluoroindan-1-one;4,6-difluoro-2,3-dihydro-1H-inden-1-one;4,6-difluoro-2,3-dihydroinden-1-one;1H-INDEN-1-ONE, 4,6-DIFLUORO-2,3-DIHYDRO-;MFCD04972815;4,6-Difluoro-indan-1-one;4.6-difluoro-1-indanone;SCHEMBL1225571;DTXSID60449557;HBVVKRYLYPANAE-UHFFFAOYSA-N;3-Bromothiophene-2-sulphonylchloride;AKOS010641455;AB21236;AC-2272;PS-6706;4,6-difluoro-2,3-dihydro-inden-1-one;SY023543;AM20030097;CS-0001938;FT-0645887;A26843;EN300-115420;Y10204;Z814904836

Suppliers and Price of 4,6-Difluoro-1-indanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,6-Difluoro-1-indanone
50mg
$ 45.00

TRC
4,6-Difluoro-1-indanone
500mg
$ 130.00

SynQuest Laboratories
4,6-Difluoroindan-1-one 98%
1 g
$ 88.00

SynQuest Laboratories
4,6-Difluoroindan-1-one 98%
250 mg
$ 32.00

Matrix Scientific
4,6-Difluoroindan-1-one 95+%
5g
$ 1008.00

Matrix Scientific
4,6-Difluoroindan-1-one 95+%
1g
$ 341.00

Crysdot
4,6-Difluoro-2,3-dihydro-1H-inden-1-one 95+%
5g
$ 475.00

Apolloscientific
4,6-Difluoroindan-1-one 98%
250mg
$ 29.00

Apolloscientific
4,6-Difluoroindan-1-one 98%
1g
$ 80.00

American Custom Chemicals Corporation
4,6-DIFLUORO INDAN-1-ONE 95.00%
1G
$ 508.20

Total 42 raw suppliers

Chemical Property of 4,6-Difluoro-1-indanone

Chemical Property:

Vapor Pressure:0.045mmHg at 25°C
Refractive Index:1.537
Boiling Point:237.291 °C at 760 mmHg
Flash Point:89.925 °C
PSA：17.07000
Density:1.362 g/cm³
LogP:2.09370
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:168.03867113
Heavy Atom Count:12
Complexity:205

Purity/Quality:

99%, ^*data from raw suppliers

4,6-Difluoro-1-indanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)C2=C1C(=CC(=C2)F)F
Uses 4,6-Difluoro-1-indanone is a useful research chemical.

Technology Process of 4,6-Difluoro-1-indanone

There total 4 articles about 4,6-Difluoro-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 162548-73-4
4,6-difluoroindan-1-one

Guidance literature:: With oxalyl dichloride; In dichloromethane; at 20 ℃; for 16h;

With aluminum (III) chloride; In dichloromethane; at 0 - 50 ℃; for 19h;

Reference yield:

: 134672-70-1
3-(2,4-difluorophenyl)-propionic acid

: 162548-73-4
4,6-difluoroindan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMF / 18 h / 20 °C

2: AlCl₃ / CH₂Cl₂ / 3.5 h / Heating

With aluminium trichloride; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; 2: Friedel-Crafts acylation;
DOI:10.1021/jm020067s