3-Bromo-6-fluoroquinoline

Base Information

Chemical Name:3-Bromo-6-fluoroquinoline
CAS No.:205114-16-5
Molecular Formula:C9H5BrFN
Molecular Weight:226.0451032
Hs Code.:
European Community (EC) Number:827-308-5
DSSTox Substance ID:DTXSID00592677
Wikidata:Q82486908
Mol file:205114-16-5.mol

Synonyms:3-BROMO-6-FLUOROQUINOLINE;205114-16-5;Quinoline, 3-bromo-6-fluoro-;3-bromo-6-fluoro quinoline;SCHEMBL584342;DTXSID00592677;BDFONODCJLSXEP-UHFFFAOYSA-N;AMY26098;MFCD22690570;AKOS023411685;SB70377;AS-41422;DB-252397;CS-0308812;EN300-133634;A850543;Z1618137057

Suppliers and Price of 3-Bromo-6-fluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
3-bromo-6-fluoroquinoline 95
5g
$ 2000.00

Crysdot
3-Bromo-6-fluoroquinoline 95+%
5g
$ 2320.00

Crysdot
3-Bromo-6-fluoroquinoline 95+%
250mg
$ 309.00

Crysdot
3-Bromo-6-fluoroquinoline 95+%
1g
$ 773.00

Chemenu
3-Bromo-6-fluoroquinoline 95%
1g
$ 723.00

Alichem
3-Bromo-6-fluoroquinoline
1g
$ 858.03

Alichem
3-Bromo-6-fluoroquinoline
5g
$ 2459.20

AK Scientific
3-Bromo-6-fluoroquinoline
500mg
$ 1008.00

Total 9 raw suppliers

Chemical Property of 3-Bromo-6-fluoroquinoline

Chemical Property:

Boiling Point:279.7±20.0 °C(Predicted)
PKA:1.86±0.14(Predicted)
PSA：12.89000
Density:1.647±0.06 g/cm3(Predicted)
LogP:3.13640
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:224.95894
Heavy Atom Count:12
Complexity:165

Purity/Quality:

97% ^*data from raw suppliers

3-bromo-6-fluoroquinoline 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC=C(C=C2C=C1F)Br

Technology Process of 3-Bromo-6-fluoroquinoline

There total 1 articles about 3-Bromo-6-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 399-52-0
5-fluoro-1H-indole

: 75-25-2
Bromoform

: 205114-16-5
3-bromo-6-fluoroquinoline

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; In water; toluene; at 40 ℃; for 48h;

Reference yield: 5.3%

: 1421348-79-9
tert-butyl 4-(amino(3,3-dimethylcyclobutyl)methyl)benzoate

: 205114-16-5
3-bromo-6-fluoroquinoline

: 1421348-83-5
tert-butyl 4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzoate

Guidance literature:: With chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate; In tetrahydrofuran; for 18h; Reflux;

Reference yield:

: 205114-16-5
3-bromo-6-fluoroquinoline

: 1421348-50-6
C₂₆H₂₈FN₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1: chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate / tetrahydrofuran / 18 h / Reflux

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 18 h

4: sodium hydroxide / tetrahydrofuran; methanol / 4.5 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;