ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

Base Information

Chemical Name:ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate
CAS No.:1421348-85-7
Molecular Formula:C₂₈H₃₂FN₃O₃
Molecular Weight:477.579
Hs Code.:

Synonyms:ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

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Chemical Property of ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

There total 10 articles about ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421348-84-6
4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzoic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1421348-85-7
ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 18h;

Reference yield:

: 34970-18-8
3,3-dimethylcyclobutanecarboxylic acid

: 1421348-85-7
ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / dichloromethane / 4 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 2.25 h / -30 °C

2.2: 0.42 h / -30 - -20 °C

2.3: 4.08 h / -40 - 0 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h

4.1: dichloromethane / 24 h / Reflux

5.1: sodium cyanoborohydride; ammonium acetate / methanol / 18 h / 60 °C

6.1: chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate / tetrahydrofuran / 18 h / Reflux

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 18 h

With TurboGrignard; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate; ammonium acetate; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1421348-85-7
ethyl 3-(4-((3,3-dimethylcyclobutyl)(6-fluoroquinolin-3-ylamino)methyl)benzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-benzyl-N,N,N-triethylammonium chloride / water; toluene / 48 h / 40 °C

2: chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate / tetrahydrofuran / 18 h / Reflux

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 18 h

With 1-hydroxy-7-aza-benzotriazole; chloro(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll); potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene;