rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester

Base Information

• Chemical Name: rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester
• CAS No.: 853759-57-6
• Molecular Formula: C17H24FNO6
• Molecular Weight: 357.3739632
• Mol file: 853759-57-6.mol

Synonyms:rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester;N-[(1,1-DiMethylethoxy)carbonyl]-2-fluoro-5-Methoxy-O-Methyl-DL-tyrosine Methyl Ester;N-Butoxycarbonyl-4,5-diMethoxy-2-fluoro-DL-phenylalanine Methyl Ester

Chemical Property of rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester

Chemical Property:

• PSA: 86.58000
• LogP: 2.65610
• Solubility.: Dichloromethane

Purity/Quality:

98% ^*data from raw suppliers

rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester

There total 3 articles about rac N-tert-Butoxycarbonyl-2-fluoro-5-methoxy-4-O-methyl-tyrosine Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl-2-[(tert-butoxycarbonyl)amino]-3-(2-fluoro-4,5-dimethoxyphenyl)prop-2-enoate (853759-47-4) → C17H24FNO6 (853759-57-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 5h;

DOI:10.1002/anie.201404436

Reference yield:

trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate (121056-95-9,89524-98-1) → C17H24FNO6 (853759-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 5 h

With palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; dichloromethane;

DOI:10.1002/anie.201404436

Reference yield:

2-fluoro-4,5-dimethoxybenzaldehyde (71924-62-4) → C17H24FNO6 (853759-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 5 h

With palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; dichloromethane;

DOI:10.1002/anie.201404436

upstream raw materials:

trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

2-fluoro-4,5-dimethoxybenzaldehyde

methyl-2-[(tert-butoxycarbonyl)amino]-3-(2-fluoro-4,5-dimethoxyphenyl)prop-2-enoate

Downstream raw materials:

C₁₆H₂₂FNO₆

ethyl-2-[(tert-butoxycarbonyl)amino]-3-(2-fluoro-4,5-dimethoxyphenyl)propanoate

ethyl-2-[bis(tert-butoxycarbonyl)amino]-3-(2-fluoro-4,5-dimethoxyphenyl)propanoate

Refernces