1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Base Information

Chemical Name:1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde
CAS No.:913375-89-0
Molecular Formula:C₁₆H₁₃N₃O₂
Molecular Weight:279.298
Hs Code.:

Synonyms:1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

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Chemical Property of 1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

There total 5 articles about 1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913375-88-9
1-methyl-2-phenyl-5-(pyridin-4-yl)-1,2-dihydropyrazol-3-one

: 913375-89-0
1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 20 ℃; for 0.833333h;

1-methyl-2-phenyl-5-(pyridin-4-yl)-1,2-dihydropyrazol-3-one; at 120 ℃; for 0.2h;

With sodium hydroxide; water; at 0 ℃;

Reference yield:

: 829-45-8
methyl 3-(pyridin-4-yl)-3-oxo-propionate

: 913375-89-0
1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; acetic acid / water / 0.08 h / Inert atmosphere

1.2: 2 h / 105 °C / Inert atmosphere

2.1: trichlorophosphate / 0.75 h / 0 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With pyridine; acetic acid; trichlorophosphate; In water; 1.1: Knorr condensation / 2.1: Vilsmeier-Haack reaction / 2.2: Vilsmeier-Haack reaction;
DOI:10.1021/jm201331s

Reference yield:

: 26377-17-3
ethyl 3-oxo-3-(4-pyridyl)propanoate

: 913375-89-0
1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / water / 4 h / 115 °C / Heating / reflux

2.1: trichlorophosphate / 0.83 h / 0 - 20 °C

2.2: 0.2 h / 120 °C

2.3: 0 °C

With acetic acid; trichlorophosphate; In water;