tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate
• CAS No.: 911705-40-3
• Molecular Formula: C15H20N2O3
• Molecular Weight: 276.335
• Mol file: 911705-40-3.mol

Synonyms:tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate;3-Oxo-2-Phenyl-Piperazine-1-Carboxylic Acid Tert-Butyl Ester

Chemical Property of tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate

Chemical Property:

• PSA: 58.64000
• LogP: 2.36130
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-oxo-2-phenylpiperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate

There total 7 articles about tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-phenyl-3-keto-piperazine (5368-28-5) → tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate (911705-40-3,2135284-21-6,2411591-34-7)

Guidance literature:

2-phenyl-3-keto-piperazine; With triethylamine; In dichloromethane; for 0.166667h;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 79.0%

di-tert-butyl dicarbonate (24424-99-5) + N-(2-aminoethyl)-2-bromo-2-phenylacetamide → tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate (911705-40-3,2135284-21-6,2411591-34-7)

Guidance literature:

N-(2-aminoethyl)-2-bromo-2-phenylacetamide; With potassium carbonate; In tetrahydrofuran; at 65 ℃;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 65 ℃;

Reference yield:

tert-butyl (2-(2-bromo-2-phenylacetamido)ethyl)carbamate (1238539-07-5) → tert-butyl 3-oxo-2-phenylpiperazine-1-carboxylate (911705-40-3,2135284-21-6,2411591-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 16 h / 65 °C

3: tetrahydrofuran / 5 h / 65 °C

With potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acschemneuro.5b00303

upstream raw materials:

di-tert-butyl dicarbonate

2-phenyl-3-keto-piperazine

bromo(phenyl)acetyl chloride

tert-butyl (2-(2-bromo-2-phenylacetamido)ethyl)carbamate

Downstream raw materials:

tert-butyl 4-(2-ethoxy-2-oxoethyl)-3-oxo-2-phenylpiperazine-1-carboxylate

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