3-Phenylpiperazin-2-one

Base Information

• Chemical Name: 3-Phenylpiperazin-2-one
• CAS No.: 5368-28-5
• Molecular Formula: C10H12 N2 O
• Molecular Weight: 176.218
• Hs Code.: 2933599090
• Mol file: 5368-28-5.mol

Synonyms:2-Piperazinone,3-phenyl- (7CI); Piperazinone, 3-phenyl- (8CI,9CI);2-Oxo-3-phenylpiperazine; 3-Oxo-2-phenylpiperazine; 3-Phenyl-2-piperazinone;NSC 70401

Chemical Property of 3-Phenylpiperazin-2-one

Chemical Property:

• Vapor Pressure: 1.55E-06mmHg at 25°C
• Boiling Point: 397.7°Cat760mmHg
• Flash Point: 182.5°C
• PSA: 41.13000
• Density: 1.106g/cm³
• LogP: 1.10470
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-Phenylpiperazin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenylpiperazin-2-one

There total 10 articles about 3-Phenylpiperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxy-3-phenylpyrazine (2882-18-0,73200-73-4) → 2-phenyl-3-keto-piperazine (5368-28-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201801134

Reference yield: 90.0%

2-(methylsulfonyl)-3-phenyl-2-(p-tolylsulfonyl)oxirane + ethylenediamine (107-15-3,85404-18-8) → 2-phenyl-3-keto-piperazine (5368-28-5)

Guidance literature:

In chloroform; at 20 ℃; for 24h;

DOI:10.1246/bcsj.77.1897

Reference yield: 62.0%

ethylenediamine (107-15-3,85404-18-8) + ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2) → 2-phenyl-3-keto-piperazine (5368-28-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 16h; Heating / reflux;

upstream raw materials:

ethylenediamine

benzaldehyde

(E)-β-phenyl-α-(methylthio)vinyl p-tolylsulfone

ethyl 2-phenyl-2-bromoacetate

Downstream raw materials:

2-(2'-Oxo-3'-phenylpiperazino)methyl-4,4-dimethyl-4H-1,3-benzothiazine

1-methyl-6-phenyl-2,3,6,7-tetrahydro-1H-diazepin-5-one

2-phenyl-1-trimethylsilylmethylpiperazine

4-acetyl-2-phenyl-1-trimethylsilylmethylpiperazine

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