Z-LEU-PNA

Base Information

• Chemical Name: Z-LEU-PNA
• CAS No.: 1174-27-2
• Molecular Formula: C20H23N3O5
• Molecular Weight: 385.42
• Mol file: 1174-27-2.mol

Synonyms:Z-LEU-PNA;Z-L-LEUCINE 4-NITROANILIDE;Z-L-LEUCINE-P-NITROANILIDE

Chemical Property of Z-LEU-PNA

Chemical Property:

• PSA: 113.25000
• LogP: 4.86150

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-LEU-PNA

There total 1 articles about Z-LEU-PNA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Z-Leu-OH (2018-66-8) + N,N'-bis(4-nitrophenyl)phospheneimidous amide (134393-23-0) → Z-L-Leu-pNA (1174-27-2)

Guidance literature:

With pyridine; at 40 ℃; for 1.5h;

DOI:10.1246/bcsj.64.1422

Reference yield:

Z-L-Leu-pNA (1174-27-2) → (S)-2-amino-4-methyl-N-(4-nitrophenyl)valeramide (4178-93-2,110893-28-2,86237-92-5,63324-49-2,6664-98-8)

Guidance literature:

With hydrogen bromide; In acetic acid;

DOI:10.1248/cpb.30.4060

Reference yield:

Z-L-Leu-pNA (1174-27-2) → Boc-Leu-Leu-pNA (85697-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 25percent HBr / acetic acid

2: 72.5 percent / DCC, HOBt / dimethylformamide / Ambient temperature

With hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1248/cpb.30.4060

upstream raw materials:

Z-Leu-OH

N,N'-bis(4-nitrophenyl)phospheneimidous amide

Downstream raw materials:

(S)-2-amino-4-methyl-N-(4-nitrophenyl)valeramide

Boc-Leu-Leu-pNA

H-Leu-Leu-pNA*HCl

Boc-Tyr-Leu-Leu-pNA

Refernces