Ethyl 4-fluoro-2-methylbenzoylformate

Base Information

• Chemical Name: Ethyl 4-fluoro-2-methylbenzoylformate
• CAS No.: 334477-07-5
• Molecular Formula: C11H11FO3
• Molecular Weight: 196.178
• Mol file: 334477-07-5.mol

Synonyms:Ethyl 4-fluoro-2-methylbenzoylformate

Chemical Property of Ethyl 4-fluoro-2-methylbenzoylformate

Chemical Property:

• Boiling Point: 286.7±33.0 °C(Predicted)
• PSA: 43.37000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 1.87990

Purity/Quality:

Ethyl4-fluoro-2-methylbenzoylformate 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-fluoro-2-methylbenzoylformate

There total 2 articles about Ethyl 4-fluoro-2-methylbenzoylformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

monomethyl oxalyl chloride (5781-53-3) + 2-Bromo-5-fluorotoluene (452-63-1) → (4-fluoro-2-methylphenyl)oxoacetic acid methyl ester (334477-07-5)

Guidance literature:

With copper(I) bromide; iodine; magnesium; lithium bromide; In tetrahydrofuran;

DOI:10.1021/op9002032

Reference yield:

C11H13FO3 → (4-fluoro-2-methylphenyl)oxoacetic acid methyl ester (334477-07-5)

Guidance literature:

With perchloric acid; In pyridine; water; acetonitrile; for 0.5h; Inert atmosphere; Molecular sieve; Schlenk technique;

DOI:10.1002/adsc.201700175

Reference yield: 61.4%

(4-fluoro-2-methylphenyl)oxoacetic acid methyl ester (334477-07-5) + ethylenediamine (107-15-3,85404-18-8) → 3-(4-fluoro-2-methylphenyl)-5,6-dihydro-1H-pyrazin-2-one (334477-08-6)

Guidance literature:

With sodium sulfate; In toluene; at 20 ℃; Inert atmosphere; Heating;

DOI:10.1021/jm900023b

upstream raw materials:

monomethyl oxalyl chloride

2-Bromo-5-fluorotoluene

Downstream raw materials:

3-(4-fluoro-2-methylphenyl)-5,6-dihydro-1H-pyrazin-2-one

2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

3-(4-fluoro-2-methylphenyl)-piperazin-2-one

(3S)-3-(4-fluoro-2-methylphenyl)-2-piperazinone (S)-mandelate