2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

Base Information

Chemical Name:2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide
CAS No.:334476-68-5
Molecular Formula:C₂₃H₂₄F₇N₃O
Molecular Weight:491.452
Hs Code.:

Synonyms:2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

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Chemical Property of 2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

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Technology Process of 2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

There total 10 articles about 2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2-(S)-(4-Fluoro-2-methyl-phenyl)-3-oxo-piperazine-1-carboxylic Acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

: 334476-68-5
2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

Guidance literature:: With borane-THF; In tetrahydrofuran;
DOI:10.1021/op800146d

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 334476-68-5
2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: magnesium; iodine; lithium bromide; copper(I) bromide / tetrahydrofuran

2: sodium sulfate / toluene

3: platinum on carbon; hydrogen / methanol / 1 h / 40 °C / 1875.19 Torr

4: triethylamine; bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine / dichloromethane

5: borane-THF / tetrahydrofuran

With borane-THF; bis(trichloromethyl) carbonate; platinum on carbon; hydrogen; iodine; magnesium; sodium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; copper(I) bromide; lithium bromide; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: |Grignard Reaction;
DOI:10.1021/op800146d

Reference yield:

: 30897-90-6
(2-methyl-4-fluorophenyl)magnesium bromide

: 334476-68-5
2-(S)-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride / tetrahydrofuran; water / 0 - 25 °C

2: acetic acid / methanol / 25 °C / Reflux

3: platinum on carbon; hydrogen / methanol / 1 h / 40 °C / 1875.19 Torr

4: triethylamine; bis(trichloromethyl) carbonate; N-ethyl-N,N-diisopropylamine / dichloromethane

5: borane-THF / tetrahydrofuran

With borane-THF; bis(trichloromethyl) carbonate; platinum on carbon; hydrogen; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/op800146d