8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane

Base Information

• Chemical Name: 8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane
• CAS No.: 1257300-52-9
• Molecular Formula: C11H19NO6S
• Molecular Weight: 293.33666
• Mol file: 1257300-52-9.mol

Synonyms:8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane;tert-Butyl 1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate 2,2-dioxide

Chemical Property of 8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane

Chemical Property:

• Boiling Point: 414.7±45.0 °C(Predicted)
• PKA: -0.92±0.20(Predicted)
• PSA: 90.52000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 2.06640

Purity/Quality:

99%, ^*data from raw suppliers

8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane

There total 2 articles about 8-Boc-2,2-dioxo-1,3-dioxa-2-thia-8-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,1-dimethylethyl 1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate-2-oxide (1257300-51-8) → 1,1-dimethylethyl 1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate 2,2-dioxide (1257300-52-9)

Guidance literature:

With sodium periodate; rhodium(III) chloride hydrate; In water; acetonitrile; at 20 ℃; for 3h;

Reference yield:

tert-butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate (389889-80-9) → 1,1-dimethylethyl 1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate 2,2-dioxide (1257300-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2: sodium periodate; rhodium(III) chloride hydrate / acetonitrile; water / 3 h / 20 °C

With sodium periodate; thionyl chloride; rhodium(III) chloride hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetonitrile;

upstream raw materials:

1,1-dimethylethyl 1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate-2-oxide

tert-butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate

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