1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE
• CAS No.: 389889-80-9
• Molecular Formula: C11H21 N O4
• Molecular Weight: 231.292
• Hs Code.: 2933399090
• Mol file: 389889-80-9.mol

Synonyms:tert-Butyl4-hydroxy-4-(hydroxymethyl)tetrahydropyridine-1(2H)-carboxylate

Chemical Property of 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE

Chemical Property:

• Boiling Point: 350.9±27.0 °C(Predicted)
• PKA: 14.06±0.20(Predicted)
• PSA: 70.00000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 0.67860

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-Hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE

There total 8 articles about 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-(hydroxymethyl)piperidin-4-ol (89584-31-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate (389889-80-9)

Guidance literature:

With triethylamine; In methanol; at 20 ℃;

Reference yield:

tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) → tert-butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate (389889-80-9)

Guidance literature:

With water; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

(4-methylpiperidin-4-yl)methanol (297172-16-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate (389889-80-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

tert-butyl 4-methylidenepiperidine-1-carboxylate

1-phenylmethyl-4-piperidone

N-benzyl-1-oxa-6-azaspiro[2,5]-octane

4-hydroxy-4-(hydroxymethyl)-1-(phenylmethyl)piperidine

Downstream raw materials:

1,1-dimethylethyl 1,3-dioxa-2-thia-8-azaspiro[4.5]decane-8-carboxylate 2,2-dioxide

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