Acetaldehyde, (3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)- (9CI)

Base Information

• Chemical Name: Acetaldehyde, (3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)- (9CI)
• CAS No.: 345892-00-4
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.191
• Mol file: 345892-00-4.mol

Synonyms:Acetaldehyde, (3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)- (9CI)

Chemical Property of Acetaldehyde, (3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)- (9CI)

Chemical Property:

Purity/Quality:

2-(3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)-Acetaldehyde 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetaldehyde, (3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)- (9CI)

There total 2 articles about Acetaldehyde, (3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ylidene)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

[2-(3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ylidene)-ethylidene]-dimethyl-ammonium; chloride → 2-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-ylidene)acetaldehyde (345892-00-4)

Guidance literature:

With sodium carbonate; at 60 - 70 ℃;

DOI:10.1023/A:1002876901829

Reference yield:

1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine (64608-66-8) → 2-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-ylidene)acetaldehyde (345892-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: POCl₃ / 0.5 h

1.2: 58 percent / dimethylformamide / 20 °C

2.1: 42 percent / aq. Na₂CO₃ / 60 - 70 °C

With sodium carbonate; trichlorophosphate; 1.2: Vilsmeier formylation;

DOI:10.1023/A:1002876901829

upstream raw materials:

1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine