2-Methoxyquinazoline

Base Information

• Chemical Name: 2-Methoxyquinazoline
• CAS No.: 6141-15-7
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• Mol file: 6141-15-7.mol

Synonyms:2-Methoxyquinazoline

Chemical Property of 2-Methoxyquinazoline

Chemical Property:

• PSA: 35.01000
• LogP: 1.63840
• Storage Temp.: 2-8°C

Purity/Quality:

2-Methoxyquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxyquinazoline

There total 7 articles about 2-Methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(α-methyl-α-hydroxy-p-bromobenzyl)-2-methoxyquinazoline (187336-12-5) → 2-methoxy-quinazoline (6141-15-7) + para-bromoacetophenone (99-90-1)

Guidance literature:

With potassium cyanide; In N,N-dimethyl-formamide;

DOI:10.3987/COM-96-7618

Reference yield: 71.0%

2-iodobenzaldehyde (26260-02-6) + o-methylisourea hydrochloride (5329-33-9) → 2-methoxy-quinazoline (6141-15-7)

Guidance literature:

With copper(l) iodide; caesium carbonate; In methanol; at 60 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.11.133

Reference yield:

2,4-dichloroquinazoline (607-68-1) → 2-methoxy-quinazoline (6141-15-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 79 percent / NaH, 1,3-dimethylimidazolium iodide / tetrahydrofuran / 5 h / Heating

2: 71 percent / methanol / 1.67 h / Heating

3: 88 percent / diethyl ether; tetrahydrofuran / 1 h / Ambient temperature

4: 86 percent / KCN / dimethylformamide / 1 h / 80 °C

With potassium cyanide; sodium hydride; 1,3-dimethylimidazolim iodide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.199

upstream raw materials:

2-chloroquinazoline

sodium methylate

4-(α-methyl-α-hydroxy-p-bromobenzyl)-2-methoxyquinazoline

2,4-dichloroquinazoline

Downstream raw materials:

Phenyl-quinazolin-2-yl-acetonitrile

phenyl(quinazolin-2-yl)methanone