4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester
• CAS No.: 205448-64-2
• Molecular Formula: C16H17NO7
• Molecular Weight: 335.313
• Mol file: 205448-64-2.mol

Synonyms:4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester;Methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzoate

Chemical Property of 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

Chemical Property:

• Boiling Point: 547.8±50.0 °C(Predicted)
• PKA: -3?+-.0.40(Predicted)
• PSA: 100.16000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: 1.68670
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

There total 6 articles about 4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione (15568-85-1) + Methyl 4-amino-2-methoxybenzoate (27492-84-8) → methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)-amino)-2-methoxybenzoate (205448-64-2)

Guidance literature:

In isopropyl alcohol; at 50 - 80 ℃; for 2.5h; Cooling with ice;

Reference yield: 89.62%

cycl-isopropylidene malonate (2033-24-1) + Methyl 4-amino-2-methoxybenzoate (27492-84-8) + trimethyl orthoformate (149-73-5) → methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)-amino)-2-methoxybenzoate (205448-64-2)

Guidance literature:

In isopropyl alcohol; at 90 ℃; for 1h;

Reference yield: 85.0%

cycl-isopropylidene malonate (2033-24-1) + Methyl 4-amino-2-methoxybenzoate (27492-84-8) → methyl 4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)-amino)-2-methoxybenzoate (205448-64-2)

Guidance literature:

cycl-isopropylidene malonate; With orthoformic acid triethyl ester; at 90 ℃; for 3h;

Methyl 4-amino-2-methoxybenzoate; In isopropyl alcohol; for 1h; Reflux;

upstream raw materials:

5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

Methyl 4-amino-2-methoxybenzoate

cycl-isopropylidene malonate

trimethyl orthoformate

Downstream raw materials:

lenvatinib

4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide

7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid

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