5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester

Base Information

• Chemical Name: 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester
• CAS No.: 104253-47-6
• Molecular Formula: C9H10ClNO3
• Molecular Weight: 215.636
• Mol file: 104253-47-6.mol

Synonyms:5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester;Methyl 5-amino-2-chloro-4-methoxybenzoate

Chemical Property of 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester

Chemical Property:

• Boiling Point: 361.5±37.0 °C(Predicted)
• PKA: 2.75±0.10(Predicted)
• PSA: 61.55000
• Density: 1.302±0.06 g/cm3(Predicted)
• LogP: 2.29860
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Amino-2-chloro-4-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester

There total 3 articles about 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-chloro-4-methoxy-5-nitrobenzoate (90537-46-5) → methyl 5-amino-2-chloro-4-methoxybenzoate (104253-47-6)

Guidance literature:

With tin(ll) chloride; In methanol; at 65 ℃; for 2h;

Reference yield:

2-chloro-4,5-dinitrobenzoic acid (33458-98-9) → methyl 5-amino-2-chloro-4-methoxybenzoate (104253-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / 0.67 h / 50 °C

2: methanol / 3 h / 50 °C

3: tin(ll) chloride / methanol / 2 h / 65 °C

With tin(ll) chloride; potassium hydroxide; In methanol;

DOI:10.1021/jm500610n

Reference yield:

2-chloro-4-methoxy-5-nitrobenzoic acid (33458-99-0) → methyl 5-amino-2-chloro-4-methoxybenzoate (104253-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 3 h / 50 °C

2: tin(ll) chloride / methanol / 2 h / 65 °C

With tin(ll) chloride; In methanol;

DOI:10.1021/jm500610n

upstream raw materials:

methyl 2-chloro-4-methoxy-5-nitrobenzoate

2-chloro-4,5-dinitrobenzoic acid

2-chloro-4-methoxy-5-nitrobenzoic acid

Downstream raw materials:

potassium 5-amino-2-chloro-4-methoxybenzoate

2-chloro-5-hydrazinyl-4-methoxybenzoic acid hydrochloride

methyl 2-chloro-5-hydrazinyl-4-methoxybenzoate hydrochloride

methyl 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzoate

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