90537-46-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester is used as an intermediate in the synthesis of new drugs and pharmaceuticals. Its presence of functional groups allows for various chemical reactions, facilitating the development of innovative therapeutic agents.
Used in Agrochemical Industry:
2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester is utilized as a building block in the production of agrochemicals. Its unique structure and reactivity contribute to the creation of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Chemical Reactions:
2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester is employed as a reactant in various chemical reactions due to its functional groups. The chlorine atom, methoxy group, and nitro group enable it to participate in a range of reactions, making it a valuable component in the synthesis of diverse chemical compounds.
Used in Research and Development:
2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester is utilized in research and development for exploring its potential applications and properties. Its biological activity and chemical reactivity make it an interesting subject for scientific investigations, leading to the discovery of new uses and applications in various fields.

Upstream product

• 101495-62-9 methyl 2,4-dichloro-5-nitrobenzoate 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 33458-99-0 2-chloro-4-methoxy-5-nitrobenzoic acid 
• 75-36-5 acetyl chloride 
• 33458-98-9 2-chloro-4,5-dinitrobenzoic acid 

Downstream Products

• 92964-11-9 4-Methoxy-5-nitro-2--benzoesaeure-methylester 
• 92426-27-2 4-Methoxy-5-nitro-2-(toluol-4-sulfonyl)-benzylchlorid 
• 97441-98-0 4-Methoxy-5-nitro-2-(toluol-4-sulfonyl)-benzylalkohol 
• 92554-34-2 4-Methoxy-5-nitro-2--benzoesaeure 
• 92554-43-3 4-Methoxy-5-nitro-2--benzoesaeure 
• 92964-32-4 4-Methoxy-5-nitro-2--benzoesaeure-methylester 
• 104253-47-6 methyl 5-amino-2-chloro-4-methoxybenzoate 
• 1143025-74-4 2-chloro-5-hydrazinyl-4-methoxybenzoic acid hydrochloride 
• 1143025-76-6 methyl 2-chloro-5-hydrazinyl-4-methoxybenzoate hydrochloride 
• 1143025-71-1 potassium 5-amino-2-chloro-4-methoxybenzoate 
• 1143025-78-8 methyl 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzoate 
• 1143025-79-9 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzamide 
• 1143023-95-3 2-chloro-4-methoxy-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide 

Relevant academic research and scientific papers

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure-activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.

BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS

A compound of formula (I) or a pharmaceutically acceptable salt thereof in which R1, R2 , R3, R4 and m are as described in the specification for use in the treatment of obesity and/or diabetes.