90537-46-5

Basic information

• Product Name: 2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester
• Synonyms: 2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester;p-Anisic acid, 2-chloro-5-nitro-, methyl ester;Methyl 2-chloro-4-methoxy-5-nitrobenzoate
• CAS NO: 90537-46-5
• Molecular Formula: C₉H₈ClNO₅
• Molecular Weight: 245.61652
• Mol File: 90537-46-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester(90537-46-5)
• EPA Substance Registry System: 2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester(90537-46-5)

Safety Data

• Hazardous Substances Data: 90537-46-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester is a chemical compound with the molecular formula C9H8ClNO5. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-Chloro-4-Methoxy-5-nitro-benzoic acid Methyl ester is a methyl ester, which means that it is a derivative of benzoic acid in which the hydrogen of the carboxylic acid group has been replaced with a methyl group. The presence of a chlorine atom, a methoxy group, and a nitro group in the compound's structure makes it useful for various chemical reactions and applications. In addition, this compound exhibits biological activity, which makes it a valuable intermediate in the production of new drugs and pharmaceuticals.

Upstream product

• 33458-98-9 2-chloro-4,5-dinitrobenzoic acid 
• 33458-99-0 2-chloro-4-methoxy-5-nitrobenzoic acid 
• 75-36-5 acetyl chloride 
• 67-56-1 methanol 
• 101495-62-9 methyl 2,4-dichloro-5-nitrobenzoate 
• 124-41-4 sodium methylate 

Downstream Products

• 92964-11-9 4-Methoxy-5-nitro-2--benzoesaeure-methylester 
• 92426-27-2 4-Methoxy-5-nitro-2-(toluol-4-sulfonyl)-benzylchlorid 
• 97441-98-0 4-Methoxy-5-nitro-2-(toluol-4-sulfonyl)-benzylalkohol 
• 92554-34-2 4-Methoxy-5-nitro-2--benzoesaeure 
• 92554-43-3 4-Methoxy-5-nitro-2--benzoesaeure 
• 92964-32-4 4-Methoxy-5-nitro-2--benzoesaeure-methylester 
• 104253-47-6 methyl 5-amino-2-chloro-4-methoxybenzoate 
• 1143025-74-4 2-chloro-5-hydrazinyl-4-methoxybenzoic acid hydrochloride 
• 1143025-76-6 methyl 2-chloro-5-hydrazinyl-4-methoxybenzoate hydrochloride 
• 1143025-71-1 potassium 5-amino-2-chloro-4-methoxybenzoate 
• 1143025-78-8 methyl 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzoate 
• 1143025-79-9 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzamide 
• 1143023-95-3 2-chloro-4-methoxy-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide 

Relevant articles and documents

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure-activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.