benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

Base Information

Chemical Name:benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate
CAS No.:1181326-92-0
Molecular Formula:C₃₅H₂₉N₅O₅
Molecular Weight:599.646
Hs Code.:
Mol file:1181326-92-0.mol

Synonyms:benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

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Chemical Property of benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

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Technology Process of benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

There total 7 articles about benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1181329-13-4
6-bromo-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine

: 1181329-12-3
benzyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamido)benzoate

: 1181326-92-0
benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

Guidance literature:: 6-bromo-N-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyrazin-8-amine; benzyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamido)benzoate; With sodium carbonate; In 1,4-dioxane; dichloromethane; water; for 0.0833333h; Inert atmosphere;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; for 2.5h; Reflux;

Reference yield:

: 14786-27-7
benzyl 4-nitrobenzoate

: 1181326-92-0
benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: iron; sulfuric acid / ethanol; water / 2.5 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 13 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; iron; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500228a

Reference yield:

: 19008-43-6
benzyl 4-aminobenzoate

: 1181326-92-0
benzyl 4-(3-(8-((3,4-dimethoxyphenyl)amino)imidazo[1,2-a]-pyrazin-6-yl)benzamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 13 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm500228a