6-Benzyl-2-methylpyridine

Base Information

• Chemical Name: 6-Benzyl-2-methylpyridine
• CAS No.: 10131-46-1
• Molecular Formula: C13H13 N
• Molecular Weight: 183.253
• Hs Code.: 2933399090
• European Community (EC) Number: 233-368-8
• UNII: AH8SZ2KS59
• DSSTox Substance ID: DTXSID00143840
• Nikkaji Number: J227.061G
• Wikidata: Q83007848
• Mol file: 10131-46-1.mol

Synonyms:6-Benzyl-2-methylpyridine;2-benzyl-6-methylpyridine;10131-46-1;2-methyl-6-(phenylmethyl)pyridine;EINECS 233-368-8;AH8SZ2KS59;2-methyl-6-benzylpyridine;UNII-AH8SZ2KS59;SCHEMBL1563589;DTXSID00143840;Pyridine, 2-methyl-6-(phenylmethyl)-

Chemical Property of 6-Benzyl-2-methylpyridine

Chemical Property:

• Vapor Pressure: 0.00872mmHg at 25°C
• Boiling Point: 275.1°C at 760 mmHg
• Flash Point: 111.3°C
• PSA: 12.89000
• Density: 1.027g/cm³
• LogP: 2.98080
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 183.104799419
• Heavy Atom Count: 14
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)CC2=CC=CC=C2

Technology Process of 6-Benzyl-2-methylpyridine

There total 21 articles about 6-Benzyl-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl 6-methyl-2-pyridyl sulphoxide (112498-13-2) → 2-benzyl-6-methylpyridine (10131-46-1)

Guidance literature:

With phenylmagnesium bromide; In tetrahydrofuran; for 0.25h; Ambient temperature;

Reference yield: 93.0%

2,4-dimethyl-3-[(6-methylpyridin-2-yl)methyl]pentan-3-ol + chlorobenzene (108-90-7) → 2-benzyl-6-methylpyridine (10131-46-1)

Guidance literature:

With caesium carbonate; tricyclohexylphosphine; palladium(II) trifluoroacetate; In toluene; xylene; for 10h; Heating;

DOI:10.1002/anie.200604472

Reference yield: 92.0%

bromobenzene (108-86-1,52753-63-6) + potassium 2-(6-methylpyridin-2-yl)acetate (1251919-66-0) → 2-benzyl-6-methylpyridine (10131-46-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In diethylene glycol dimethyl ether; at 150 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja107103b

upstream raw materials:

1-benzyl-2-methylpyridinium chloride

2-benzyl-6-methylpyridine N-oxide

2-Benzyl-1,6-dimethyl-pyridinium; iodide

1-Ethyl-2-benzyl-6-methylpyridine

Downstream raw materials:

2-(2,4-dinitrobenzyl)-6-methylpyridine

(6-methylpyridin-2-yl)(phenyl)methanone

2-benzyl-6-methylpyridine N-oxide

4-methyl-N-(2-(6-methylpyridin-2-yl)-1,2-diphenylethyl)benzenesulfonamide

Refernces

• 1、 Liu, Wenbo,Yang, Xiaobo,Zhou, Zhong-Zhen,Li, Chao-Jun. "Simple and Clean Photo-induced Methylation of Heteroarenes with MeOH". . p. 688 - 702. Retrieved 2017.
• 2、 Jia, Kai,Jiang, Chao,Ma, Wenchao,Yan, Yintao,Zhang, Chenming. "A Mild and Efficient Synthesis of Pyrazolo[1,5- a ]pyridines Mediated by Triphenylphosphine/Diiodine". supporting information. . Retrieved 2022/01/12.
• 3、 Zhou, Wang,Miura, Tomoya,Murakami, Masahiro. "Photocatalyzed ortho-Alkylation of Pyridine N-Oxides through Alkene Cleavage". supporting information. p. 5139 - 5142. Retrieved 2018/05/30.