(3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE

Base Information

• Chemical Name: (3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE
• CAS No.: 70344-79-5
• Molecular Formula: C15H10ClNO2
• Molecular Weight: 271.703
• Mol file: 70344-79-5.mol

Synonyms:(3-AMINO-BENZOFURAN-2-YL)-(4-CHLORO-PHENYL)-METHANONE;(3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE;AKOS BBS-00001266;3-AMINO-2-(4-CHLOROBENZOYL)BENZOFURAN;AKOS BBV-017102

Chemical Property of (3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE

Chemical Property:

• PSA: 56.23000
• LogP: 4.48060

Purity/Quality:

97% ^*data from raw suppliers

(3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE

There total 4 articles about (3-AMINO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

salicylonitrile (611-20-1) + 4-chlorobenzoylmethyl bromide (536-38-9) → 3-aminobenzofuran-2-yl(4-chlorophenyl)methanone (70344-79-5)

Guidance literature:

With potassium carbonate; In acetone; for 18h; Inert atmosphere; Reflux;

Reference yield:

2-(2-(4-chlorophenyl)-2-oxoethoxy)benzonitrile (70344-87-5) → 3-aminobenzofuran-2-yl(4-chlorophenyl)methanone (70344-79-5)

Guidance literature:

With sodium methylate; In methanol; for 1h;

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → 3-aminobenzofuran-2-yl(4-chlorophenyl)methanone (70344-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: sodium methylate / methanol / 1 h

With sodium methylate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

salicylonitrile

4-chlorobenzoylmethyl bromide

2-(2-(4-chlorophenyl)-2-oxoethoxy)benzonitrile

Downstream raw materials:

ethyl [1-(1H-1,2,3-benzotriazol-1-yl)-2-({2-[(4-chlorophenyl)carbonyl]-1-benzofuran-3-yl}amino)-2-oxoethyl]carbamate