2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid

Base Information

Chemical Name:2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
CAS No.:1239233-87-4
Molecular Formula:C16H17NO5S
Molecular Weight:335.381
Hs Code.:
Mol file:1239233-87-4.mol

Synonyms:2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid;Febuxostat Dicarboxylic Acid Impurity;2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid

Suppliers and Price of 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicAcid
10mg
$ 185.00

Medical Isotopes, Inc.
2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicAcid
100 mg
$ 2200.00

AvaChem
Febuxostat impurity B
25mg
$ 425.00

AvaChem
Febuxostat impurity B
10mg
$ 225.00

AvaChem
Febuxostat impurity B
5mg
$ 125.00

A1 Biochem Labs
Febuxostatdiacidimpurity 95%
500 mg
$ 1500.00

A1 Biochem Labs
Febuxostatdiacidimpurity 95%
250 mg
$ 1000.00

Total 20 raw suppliers

Chemical Property of 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid

Chemical Property:

Boiling Point:568.9±60.0 °C(Predicted)
PKA:1.21±0.37(Predicted)
PSA：124.96000
Density:1.327±0.06 g/cm3(Predicted)
LogP:3.54970
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.

Technology Process of 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid

There total 2 articles about 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

: 144060-53-7
febuxostat

: 1239233-87-4
2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 10h;
DOI:10.1134/S0022476621100103

Reference yield:

: 160844-75-7
2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

: 1239233-87-4
2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid

Guidance literature:: 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester; With sodium hydroxide; In tetrahydrofuran; for 48h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; pH=~ 3;

Reference yield: 96.0%

: 1239233-87-4
2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid

: 144060-53-7
febuxostat

Guidance literature:: With sodium azide; trifluorormethanesulfonic acid; In water; acetonitrile; at 30 ℃; for 8h; Temperature; Reagent/catalyst; Solvent;