5-Methoxy-6-nitro-2,3-dihydro-1H-indole

Base Information

• Chemical Name: 5-Methoxy-6-nitro-2,3-dihydro-1H-indole
• CAS No.: 23772-38-5
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.1873
• Mol file: 23772-38-5.mol

Synonyms:5-Methoxy-6-nitro-2,3-dihydro-1H-indole;5-Methoxy-6-nitroindoline;2,3-dihydro-5-methoxy-6-nitro-1H-indole

Chemical Property of 5-Methoxy-6-nitro-2,3-dihydro-1H-indole

Chemical Property:

• Boiling Point: 365.8±42.0 °C(Predicted)
• PKA: 4.17±0.20(Predicted)
• Density: 1.291±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

5-methoxy-6-nitro-2,3-dihydro-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-Methoxy-6-nitro-2,3-dihydro-1H-indole

There total 3 articles about 5-Methoxy-6-nitro-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-acetyl-5-methoxy-6-nitro-2,3-dihydro-indole (23772-37-4) → 5-methoxy-6-nitro-2,3-dihydro-indole (23772-38-5)

Guidance literature:

With hydrogenchloride; In MeOH; Reflux;

DOI:10.1016/j.bmcl.2008.11.077

Reference yield:

1-acetyl-2,3-dihydro-5-methoxy-1H-indole (4770-33-6) → 5-methoxy-6-nitro-2,3-dihydro-indole (23772-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; acetic anhydride

2: hydrogenchloride / MeOH / Reflux

With hydrogenchloride; nitric acid; acetic anhydride; In MeOH;

DOI:10.1016/j.bmcl.2008.11.077

Reference yield:

→ 5-methoxy-6-nitro-2,3-dihydro-indole (23772-38-5)

Guidance literature:

1-Acetyl-5-methoxy-6-nitro-indolin (I), 6n wss. HCl, Ausb. 100percent;

upstream raw materials:

1-acetyl-2,3-dihydro-5-methoxy-1H-indole

1-acetyl-5-methoxy-6-nitro-2,3-dihydro-indole

Downstream raw materials:

1-[(dimethylamino)acetyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-amine

C₁₉H₃₀N₄O₂

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