2-Iodo-5-BroMobenzyl chloride

Base Information

• Chemical Name: 2-Iodo-5-BroMobenzyl chloride
• CAS No.: 1261817-10-0
• Molecular Formula: C7H5BrClI
• Molecular Weight: 331.378
• Hs Code.: 2903998090
• Mol file: 1261817-10-0.mol

Synonyms:2-Iodo-5-BroMobenzyl chloride;4-Bromo-2-(chloromethyl)-1-iodobenzene

Chemical Property of 2-Iodo-5-BroMobenzyl chloride

Chemical Property:

• Boiling Point: 324.0±27.0 °C(Predicted)
• PSA: 0.00000
• Density: 2.132±0.06 g/cm3(Predicted)
• LogP: 3.79250

Purity/Quality:

99%, ^*data from raw suppliers

2-Iodo-5-bromobenzyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Iodo-5-BroMobenzyl chloride

There total 1 articles about 2-Iodo-5-BroMobenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-bromo-2-iodo-phenyl)-methanol (199786-58-8) → 4-bromo-2-(chloromethyl)-1-iodobenzene (1261817-10-0)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.joc.5b02378

Reference yield: 77.0%

4-bromo-2-(chloromethyl)-1-iodobenzene (1261817-10-0) + phenyl 3-oxoazetidine-1-carboxylate → phenyl 6-bromospiro[1H-isobenzofuran-3,3'-azetidine]-1'-carboxylate

Guidance literature:

4-bromo-2-(chloromethyl)-1-iodobenzene; With TurboGrignard; In tetrahydrofuran; at -35 - -25 ℃; for 1.5h; Large scale;

phenyl 3-oxoazetidine-1-carboxylate; In tetrahydrofuran; at -25 - 35 ℃; for 19h; Temperature; Large scale;

Reference yield:

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + 4-bromo-2-(chloromethyl)-1-iodobenzene (1261817-10-0) → C15H21BrClNO2

Guidance literature:

4-bromo-2-(chloromethyl)-1-iodobenzene; With TurboGrignard; In tetrahydrofuran; toluene; at -30 ℃; for 0.0222222h;

tert-butyl 3-oxoazetidine-1-carboxylate; In tetrahydrofuran; toluene; at -30 ℃; for 0.0833333h; Temperature;

upstream raw materials:

(5-bromo-2-iodo-phenyl)-methanol

Downstream raw materials:

tert-butyl 5'-acetyl-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate

tert-butyl 6-[(E/Z)-3-(3,5-dichloro-4-fluoro-phenyl)-4,4,4-trifluoro-but-2-enoyl]spiro[1H-isobenzofuran-3,3'-azetidine]-1'-carboxylate

tert-butyl 6-bromospiro[1H-isobenzofuran-3,3‘-azetidine]-1‘-carboxylate

tert-butyl 5'-[3-(3,5-dichloro-4-fluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]-1-carboxylate