199786-58-8

Usage

Uses

Used in Chemical Synthesis:
5-Bromo-2-iodobenzenemethanol is used as a building block for the synthesis of other organic compounds, contributing to the creation of a diverse range of chemical products due to its unique molecular structure featuring both halogen atoms.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 5-Bromo-2-iodobenzenemethanol is employed as a precursor in the development of new drugs, leveraging its chemical properties to form the basis of potential medicinal agents.
Used in Specialty Chemicals Production:
5-BROMO-2-IODOBENZENEMETHANOL also finds application in the production of specialty chemicals, where its distinctive attributes can be harnessed to create high-value products for specific industries.
Safety Considerations:
It is crucial to handle and store 5-Bromo-2-iodobenzenemethanol with care, as it is potentially hazardous and can cause skin and eye irritation, necessitating proper safety measures during its use and disposal.

Upstream product

• 116632-39-4 2-methyl-4-bromoiodobenzene 
• 495414-06-7 4-bromo-2-(bromomethyl)-1-iodobenzene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 118-92-3 anthranilic acid 
• 181765-86-6 5-bromo-2-iodo-benzoic acid methyl ester 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 

Downstream Products

• 689291-89-2 5-bromo-2-iodobenzaldehyde 
• 885693-79-8 2,5-bis((trimethylsilyl)ethynyl)benzaldehyde 
• 1038395-11-7 5-bromo-2-((triisopropylsilyl)ethynyl)benzaldehyde 
• 1038395-08-2 1,4-bis(5-bromo-2-iodostyryl)benzene 
• 1038395-09-3 C₄₂H₅₀Si₄ 
• 1038395-10-6 C₃₀H₁₈ 
• 1038395-15-1 C₆₂H₄₂O₈ 
• 1263055-18-0 2,5-diethynylbenzaldehyde 
• 1263055-20-4 C₂₇H₁₈O₅ 
• 1263055-24-8 2-((triisopropylsilyl)ethynyl)-5-((trimethylsilyl)ethynyl)benzaldehyde 
• 1263055-26-0 5-ethynyl-2-((triisopropylsilyl)ethynyl)benzaldehyde 
• 1263055-28-2 methyl 2-((3-formyl-4-((triisopropylsilyl)ethynyl)phenyl)ethynyl)benzoate 
• 1263055-30-6 methyl 2-((4-ethynyl-3-formylphenyl)ethynyl)benzoate 
• 1263055-32-8 C₂₇H₂₁NO₃ 

Relevant academic research and scientific papers

A new solvatochromic linear π-conjugated dye based on phenylene-(poly)ethynylene as supersensitive low-level water detector in organic solvents

A novel class of phenylene-(poly)ethynylene-based dye Sensor 1 with remarkable properties of solvatochromism has been designed and synthesized. A long, coplanar and asymmetry electron-rich π-conjugated structure endows Sensor 1 with maximum solvatochromic

INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE - SYNTHESIS AND USE THEREOF FOR TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOMA

The present invention relates to new compounds of general formula I, their synthesis, their pharmaceutically acceptable salts, and their use in treatment of T-cell acute lymphoblastic leukemia and lymphoma.

Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)-H Arylation with a Transient Directing Group

Methylene-selective C-H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) catalysis. We report a Pd(II)-catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)-H arylation of ketones. The reaction utilizes glycine as a transient directing group and a 2-pyridone ligand, which may govern the methylene selectivity by making intimate molecular associations with the substrate during concerted metalation-deprotonation. This reaction is shown to be highly selective for intramolecular methylene C(sp3)-H arylation, thus enabling sequential C(sp3)-H functionalization.

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

One-Pot Synthesis and Conformational Analysis of Six-Membered Cyclic Iodonium Salts

Two one-pot procedures for the construction of carbon-bridged diaryliodonium triflates and tetrafluoroborates are described. Strong Br?nsted acids enable the effective Friedel-Crafts alkylation with diversely substituted o-iodobenzyl alcohol derivatives, providing diphenylmethane scaffolds, which are subsequently oxidized and cyclized to the corresponding dibenzo[b,e]iodininium salts. Based on NMR investigations and density functional theory (DFT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic iodonium salts substituted with aliphatic side chains in the carbon bridge.

CuSO4-Catalyzed dual annulation to synthesize O, S or N-containing tetracyclic heteroacenes

In this work, CuSO4 is utilized as a practical redox catalyst for tandem dual annulation in the synthesis of indole-fused tetracyclic heteroacenes, which are important skeletons in both medicinal chemistry and materials chemistry. The preparation of such skeletons in a convenient and efficient manner is in high demand. This method realizes the modular synthesis of benzofuro-, benzothieno-, and indoloindoles from abundant feedstocks such as 2-halobenzyl halides and nitrile derivatives in up to 99% yields, providing a rapid access to diverse indole-fused heteroacenes with biological or optoelectronic properties.

ISOQUINOLINE DERIVATIVES AS PERK INHIBITORS

The invention is directed to substituted isoquinoline derivatives and uses thereof. Specifically, the invention is directed to compounds according to Formula I and the use of compounds of Formula (I) in treating disease states: (I) wherein R1,

Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes

A Cu-catalyzed enantioselective desymmetrizing ring-opening reaction of six-membered cyclic diaryliodonium salts with carboxylic acids or thioacids is reported for the facile access to chiral diarylmethanes. A Cu/[cyclopropyl bis(oxazoline)] catalyst well

Phenanthroline- tBuOK Promoted Intramolecular C-H Arylation of Indoles with ArI under Transition-Metal-Free Conditions

The first example of phenanthroline-tBuOK promoted intramolecular radical C-H arylation of N-(2-iodobenzyl)indoles without involvement of transition metals has been developed. A variety of substituted 6H-isoindolo [2, 1-a] indoles were prepared by a simple and efficient intramolecular cyclization using 1,10-phenanthroline in the presence of potassium tert-butoxide and chlorobenzene. This strategy provides a fast and versatile access to isoindolo[2,1-a]indole derivatives for the synthesis of pharmaceuticals and organic electroluminescent (EL) materials.

Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds

A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds using a novel palladium-catalyzed tandem cyclization reaction is explored. During the reaction process, C-O, C-C and C-O bonds are sequentially formed in one pot via decarboxylative allenylpalladium formation, nucleophilic attack, arylpalladium addition and intramolecular nucleophilic attack.