(R)-6-ETHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE

Base Information

• Chemical Name: (R)-6-ETHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE
• CAS No.: 18426-16-9
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.354
• Mol file: 18426-16-9.mol

Synonyms:(R)-6-ETHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE;4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL, 6-ETHYL-5,6,6A,7-TETRAHYDRO-, HYDROCHLORIDE, (R)-;R(-)-N-ETHYLNORAPOMORPHINE HYDROCHLORIDE

Chemical Property of (R)-6-ETHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE

Chemical Property:

• PSA: 43.70000
• LogP: 3.17790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-ETHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE

There total 3 articles about (R)-6-ETHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-N-(2-hydroxyethyl)norapocodeine (73378-10-6) → (-)-N-ethylnorapomorphine (18426-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 48percent aq. HBr

2: 1.) CF₃COOH, Br₂, 2.) SOCl₂, 3.) H₂/T₂, 10percent Pd/C

With palladium on activated charcoal; thionyl chloride; tritium; hydrogen bromide; hydrogen; bromine; trifluoroacetic acid;

DOI:10.1021/jm00372a019

Reference yield:

(-)-N-Hydroxyethylnorapomorphine hydrochloride (75846-02-5) → [3H]-N-Chloroethylnorapomorphine (75946-94-0) + (-)-N-ethylnorapomorphine (18426-16-9) + (-)-N-ethyl<3H>norapomorphine (89849-68-3) + (-)-N-(2-chloroethyl)<8,9-3H>norapomorphine (89849-65-0)

Guidance literature:

With palladium on activated charcoal; thionyl chloride; tritium; hydrogen; bromine; trifluoroacetic acid; Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jm00372a019

Reference yield:

→ N-Aethylnorapomorphin (18426-16-9)

Guidance literature:

entspr. N-substit. Normorphin/85percentig. H3PO4, 1. 145-150grad/N2-Strom, 2. HCl;

DOI:10.1021/jm00244a010

upstream raw materials:

(-)-N-Hydroxyethylnorapomorphine hydrochloride

(-)-N-(2-hydroxyethyl)norapocodeine