75946-94-0

Basic information

• Product Name: chloroethylnorapomorphine
• Synonyms: chloroethylnorapomorphine
• CAS NO: 75946-94-0
• Molecular Formula: C18H18ClNO2
• Molecular Weight: 315.79402
• Mol File: 75946-94-0.mol

Chemical Properties

• Boiling Point: 525.8°C at 760 mmHg
• Flash Point: 271.8°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 1.13E-11mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: chloroethylnorapomorphine(CAS DataBase Reference)
• NIST Chemistry Reference: chloroethylnorapomorphine(75946-94-0)
• EPA Substance Registry System: chloroethylnorapomorphine(75946-94-0)

Safety Data

• Hazardous Substances Data: 75946-94-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H18ClNO2/c19-7-9-20-8-6-11-2-1-3-13-16(11)14(20)10-12-4-5-15(21)18(22)17(12)13/h1-5,14,21-22H,6-10H2/t14-/m1/s1

Upstream product

• 73566-60-6 N-(hydroxyethyl)norapocodeine 
• 73378-06-0 N-(2-Hydroxyethyl)norcodeine 
• 467-15-2 norcodeine 
• 76-57-3 codeine 
• 79640-90-7 6-(2-Hydroxy-ethyl)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol 
• 73378-10-6 (-)-N-(2-hydroxyethyl)norapocodeine 
• 75846-02-5 (-)-N-Hydroxyethylnorapomorphine hydrochloride 

Relevant articles and documents

Aporphines. 58. N-(2-Chloroethyl)norapomorphine, an Irreversible Ligand for Dopamine Receptors: Synthesis and Application

The synthesis of the title compounds (1c and its 2H isomer 1b) from N-(2-hydroxyethyl)norapomorphine was carried out by ring bromination, followed by chlorination to the 2-chloroethyl compound 6.Further reduction with 2H2 or 3H2 and Pd/C gave 1b or 1c.Radiochemically pure (97percent) 1c was obtained with a specific activity of 16.3 Ci/mmol.The purity of 1c was determined by LC, HPLC, UV, and NMR. NCA was shown to label the D2 receptor; however, the D2 signal appears to be only a small portion of the total signal, which may include binding to other dopamine receptor subtypes (D1 and D3).