GNE 900

Base Information

Chemical Name:GNE 900
CAS No.:1200126-26-6
Molecular Formula:C₂₃H₂₁N₅
Molecular Weight:367.453
Hs Code.:
Mol file:1200126-26-6.mol

Synonyms:GNE 900

Suppliers and Price of GNE 900

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 24 raw suppliers

Chemical Property of GNE 900

Chemical Property:

PSA：68.60000
LogP:4.57358

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of GNE 900

There total 8 articles about GNE 900 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1200130-52-4
3-bromo-9H-pyrrolo[2,3-b:5,4-c′]dipyridine-6-carbonitrile

: 1200434-84-9
(4-(piperidin-1-ylmethyl)phenyl)boronic acid

: 1200126-26-6
3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine-6-carbonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; for 8h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: methyl 2-amino-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoate bis hydrochloride salt

: 1200126-26-6
3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 1 h / 100 °C

2: pyridine; selenium(IV) oxide / 1,4-dioxane / 100 °C

3: acetic acid; sodium acetate; bromine / 1.5 h / 100 °C

4: ammonia / methanol / 140 °C / Autoclave

5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 4 h / 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 8 h / Inert atmosphere; Reflux

With pyridine; selenium(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonia; bromine; sodium acetate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; water; 6: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 7-azatryptophan hydrate

: 1200126-26-6
3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 0.5 h / 0 °C / Reflux

2: pyridine / 1 h / 100 °C

3: pyridine; selenium(IV) oxide / 1,4-dioxane / 100 °C

4: acetic acid; sodium acetate; bromine / 1.5 h / 100 °C

5: ammonia / methanol / 140 °C / Autoclave

6: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 4 h / 20 °C

7: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 8 h / Inert atmosphere; Reflux

With pyridine; selenium(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; ammonia; bromine; sodium acetate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; water; 7: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464